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具有2-氟腺嘌呤衍生物的碳环和无环核苷的合成及其对恶性疟原虫SAH水解酶的抑制活性。

Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.

作者信息

Kitade Yukio, Kojima Hiroharu, Zulfiqur Fazila, Yabe Saori, Yamagiwa Daisuke, Ito Yasutomo, Nakanishi Masayuki, Ueno Yoshihito, Kim Hye-Sook, Wataya Yusuke

机构信息

Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan.

出版信息

Nucleic Acids Res Suppl. 2003(3):5-6. doi: 10.1093/nass/3.1.5.

DOI:10.1093/nass/3.1.5
PMID:14510352
Abstract

Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.

摘要

合成了具有2-氟腺嘌呤的碳环和无环核苷，如2-氟去甲阿瑞他汀（6）和2-氟-9-[(2S,3R)-2,3,4-三羟基丁基-1-基]腺嘌呤（8），并研究了它们对人和恶性疟原虫重组SAH水解酶的抑制活性。

相似文献

1
Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.具有2-氟腺嘌呤衍生物的碳环和无环核苷的合成及其对恶性疟原虫SAH水解酶的抑制活性。
Nucleic Acids Res Suppl. 2003(3):5-6. doi: 10.1093/nass/3.1.5.
2
Synthesis of carbocyclic nucleosides and their SAH hydrolase inhibitory activities.碳环核苷的合成及其对SAH水解酶的抑制活性。
Nucleic Acids Symp Ser. 2000(44):111-2. doi: 10.1093/nass/44.1.111.
3
Synthesis of S-adenosyl-L-homocysteine hydrolase inhibitors and their biological activities.S-腺苷-L-高半胱氨酸水解酶抑制剂的合成及其生物活性。
Nucleic Acids Symp Ser. 1999(42):25-6. doi: 10.1093/nass/42.1.25.
4
Synthesis of 2-fluoronoraristeromycin and its inhibitory activity against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.2-氟去甲阿霉素的合成及其对恶性疟原虫S-腺苷-L-高半胱氨酸水解酶的抑制活性
Bioorg Med Chem Lett. 2003 Nov 17;13(22):3963-5. doi: 10.1016/j.bmcl.2003.08.074.
5
Synthesis of noraristeromycin analogues possessing SAH hydrolase inhibitory activity for the development of antimalaria agents.具有SAH水解酶抑制活性的去甲瑞斯托霉素类似物的合成用于抗疟药物的开发。
Nucleic Acids Res Suppl. 2002(2):141-2. doi: 10.1093/nass/2.1.141.
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Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.无环磷酸（膦）酸抑制剂对恶性疟原虫次黄嘌呤-鸟嘌呤-黄嘌呤磷酸核糖基转移酶的抑制作用。
Bioorg Med Chem. 2013 Sep 1;21(17):5629-46. doi: 10.1016/j.bmc.2013.02.016. Epub 2013 Mar 5.
7
Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase.2-修饰阿瑞霉素及其类似物的合成作为恶性疟原虫S-腺苷-L-高半胱氨酸水解酶的有效抑制剂
Bioorg Med Chem. 2008 Apr 1;16(7):3809-15. doi: 10.1016/j.bmc.2008.01.046. Epub 2008 Jan 30.
8
Synthesis of DHPA analogs and their inhibitory activities of human recombinant S-adenosyl-L-homocysteine hydrolase.二氢苯丙氨酸（DHPA）类似物的合成及其对人重组S-腺苷-L-高半胱氨酸水解酶的抑制活性。
Nucleic Acids Symp Ser. 1997(37):11-2.
9
Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.新型无环核苷膦酸酯作为恶性疟原虫和人6-氧嘌呤磷酸核糖基转移酶抑制剂的合成与评价
ChemMedChem. 2015 Oct;10(10):1707-23. doi: 10.1002/cmdc.201500322. Epub 2015 Aug 25.
10
Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase.无环尿苷酰胺和 5'-酰胺核苷类似物作为疟原虫 dUTP 酶潜在抑制剂的研究。
Bioorg Med Chem. 2013 Sep 15;21(18):5876-85. doi: 10.1016/j.bmc.2013.07.004. Epub 2013 Jul 12.

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