具有2-氟腺嘌呤衍生物的碳环和无环核苷的合成及其对恶性疟原虫SAH水解酶的抑制活性。
Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.
作者信息
Kitade Yukio, Kojima Hiroharu, Zulfiqur Fazila, Yabe Saori, Yamagiwa Daisuke, Ito Yasutomo, Nakanishi Masayuki, Ueno Yoshihito, Kim Hye-Sook, Wataya Yusuke
机构信息
Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan.
出版信息
Nucleic Acids Res Suppl. 2003(3):5-6. doi: 10.1093/nass/3.1.5.
PMID:14510352
Abstract
Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.
摘要
合成了具有2-氟腺嘌呤的碳环和无环核苷，如2-氟去甲阿瑞他汀（6）和2-氟-9-[(2S,3R)-2,3,4-三羟基丁基-1-基]腺嘌呤（8），并研究了它们对人和恶性疟原虫重组SAH水解酶的抑制活性。
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