Kojima Hiroharu, Yamaguchi Tsuyoshi, Kozaki Atsushi, Nakanishi Masayuki, Ueno Yoshihito, Kitade Yukio
Laboratory of Molecular Biochemistry, Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan.
Nucleic Acids Res Suppl. 2002(2):141-2. doi: 10.1093/nass/2.1.141.
Noraristeromycin analogues such as 3',4'-anhydronoraristeromycins, 2-amino-3',4'-anhydronoraristeromycin and N6-cyclopropylnoraristeromycin were synthesized and their inhibitory activity against human and Plasmodium falciparum (P. falciparum) recombinant SAH hydrolase was investigated. Among them, 3',4'-anhydronoraristeromycin showed inhibitory activity against human recombinant S-adenosyl-L-homocysteine hydrolase (Ki = 12.4 microM, Kinact = 0.55 min-1).
合成了诺里霉素类似物，如3',4'-脱水诺里霉素、2-氨基-3',4'-脱水诺里霉素和N6-环丙基诺里霉素，并研究了它们对人和恶性疟原虫重组S-腺苷-L-高半胱氨酸水解酶的抑制活性。其中，3',4'-脱水诺里霉素对人重组S-腺苷-L-高半胱氨酸水解酶表现出抑制活性（Ki = 12.4 microM，Kinact = 0.55 min-1）。
