• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

5'-(Z)-取代的4',5'-不饱和腺苷的立体定向合成及其对S-腺苷同型半胱氨酸水解酶抑制活性的评价。

Stereo-defined synthesis of 5'-(Z)-substituted 4',5'-unsaturated adenosines and evaluation of their inhibitory activity against S-adenosyl homocysteine hydrolase.

作者信息

Kumamoto Hiroki, Onuma Sayoko, Tanaka Hiromichi, Kitade Yukio

机构信息

School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

出版信息

Nucleic Acids Res Suppl. 2003(3):13-4. doi: 10.1093/nass/3.1.13.

DOI:10.1093/nass/3.1.13
PMID:14510356
Abstract

A new approach was developed for the synthesis of 5'-(Z)-substituted 4',5'-unsaturated adenosines, potential inhibitors against S-adenosyl-L-homocysteine hydrolase (SAHase). A highly stereoselective radical-mediated sulfur-extrusive stannylation was employed as a key step in the present approach. Inhibitory activity of the compounds against SAHase is also presented.

摘要

开发了一种合成5'-(Z)-取代的4',5'-不饱和腺苷的新方法，这些腺苷是针对S-腺苷-L-高半胱氨酸水解酶（SAHase）的潜在抑制剂。一种高度立体选择性的自由基介导的硫挤出锡化反应被用作本方法的关键步骤。还介绍了这些化合物对SAHase的抑制活性。

相似文献

1
Stereo-defined synthesis of 5'-(Z)-substituted 4',5'-unsaturated adenosines and evaluation of their inhibitory activity against S-adenosyl homocysteine hydrolase.5'-(Z)-取代的4',5'-不饱和腺苷的立体定向合成及其对S-腺苷同型半胱氨酸水解酶抑制活性的评价。
Nucleic Acids Res Suppl. 2003(3):13-4. doi: 10.1093/nass/3.1.13.
2
Synthesis of novel 4'-modified neplanocin A analogues and their inhibitory activity against S-adenosyl-L-l-homocysteine hydrolase.新型4'-修饰的奈替米星A类似物的合成及其对S-腺苷-L-高半胱氨酸水解酶的抑制活性。
Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):733-6. doi: 10.1080/15257770701493617.
3
Synthesis of an alpha-aminophosphonate nucleoside as an inhibitor of S-adenosyl-L-homocysteine hydrolase.
Bioorg Med Chem Lett. 2002 Feb 11;12(3):457-60. doi: 10.1016/s0960-894x(01)00789-2.
4
Synthesis of apio analogues of neplanocin A as potential inhibitors of S-adenosylhomocysteine hydrolase.
Nucleic Acids Res Suppl. 2003(3):15-6. doi: 10.1093/nass/3.1.15.
5
Synthesis of 5'-branched neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation.基于自由基介导的硫挤出锡化反应合成5'-支链奈替米星A类似物
Nucleic Acids Symp Ser (Oxf). 2007(51):145-6. doi: 10.1093/nass/nrm073.
6
Mechanism of inactivation of S-adenosyl-L-homocysteine hydrolase by 5'-deoxy-5'-S-allenylthioadenosine and 5'-deoxy-5'-S-propynylthioadenosine.
Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):685-8. doi: 10.1081/NCN-100002351.
7
Targeting "hydrolytic" activity of the S-adenosyl-L-homocysteine hydrolase.靶向S-腺苷-L-高半胱氨酸水解酶的“水解”活性。
Mini Rev Med Chem. 2001 Sep;1(3):307-16. doi: 10.2174/1389557013406918.
8
New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor.新型奈普诺星类似物。12. 强效腺苷高半胱氨酸水解酶抑制剂(6'R)-6'-C-甲基奈普诺星A的另一种合成方法及其抗疟作用。
J Med Chem. 2002 Jan 31;45(3):748-51. doi: 10.1021/jm010374i.
9
Sugar-modified conjugated diene analogues of adenosine and uridine: synthesis, interaction with S-adenosyl-L-homocysteine hydrolase, and antiviral and cytostatic effects.腺苷和尿苷的糖修饰共轭二烯类似物：合成、与S-腺苷-L-高半胱氨酸水解酶的相互作用以及抗病毒和细胞抑制作用。
J Med Chem. 2002 Jun 6;45(12):2651-8. doi: 10.1021/jm020064f.
10
Synthesis of S-adenosyl-L-homocysteine hydrolase inhibitors and their biological activities.S-腺苷-L-高半胱氨酸水解酶抑制剂的合成及其生物活性。
Nucleic Acids Symp Ser. 1999(42):25-6. doi: 10.1093/nass/42.1.25.