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基于自由基介导的硫挤出锡化反应合成5'-支链奈替米星A类似物

Synthesis of 5'-branched neplanocin A analogues based on radical-mediated sulfur-extrusive stannylation.

作者信息

Kumamoto Hiroki, Tanaka Hiromichi

机构信息

School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.

出版信息

Nucleic Acids Symp Ser (Oxf). 2007(51):145-6. doi: 10.1093/nass/nrm073.

DOI:10.1093/nass/nrm073
PMID:18029628
Abstract

An approach was developed for the synthesis of 5'-branched neplanocin A, as potential inhibitors against S-adenosyl-L-homocysteine hydrolase. The vinyl-stannane system of the key synthetic intermediate (14) in the present study, was prepared by radical-mediated sulfur-extrusive stannylation.

摘要

开发了一种合成5'-支链奈普拉诺辛A的方法，其作为潜在的S-腺苷-L-高半胱氨酸水解酶抑制剂。本研究中关键合成中间体（14）的乙烯基锡烷体系是通过自由基介导的硫挤出锡化反应制备的。

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