以分子内糖基化作为关键步骤的胞嘧啶霉素的合成研究。
Synthetic study of cytosaminomycins using the intramolecular glycosylation as a key step.
作者信息
Sugimura Hideyuki
机构信息
Faculty of Education, Yokohama National University, Tokiwadai 79-2, Hodogaya-ku, Yokohama 240-8501, Japan.
出版信息
Nucleic Acids Res Suppl. 2003(3):21-2. doi: 10.1093/nass/3.1.21.
PMID:14510360
Abstract
2',6'-Dideoxy-beta-D-hexopyranosyl pyrimidine nucleoside, which is a component of anticoccidal antibiotics--cytosaminomycins, was synthesized in a stereoselective manner via the intramolecular pyrimidine delivery method. Further glycosylaion of the 4'-position with a glycosyl fluoride gave the disaccharide nucleoside skeleton of the cytosaminomycins.
摘要
2',6'-二脱氧-β-D-己吡喃糖基嘧啶核苷是抗球虫抗生素——胞嘧啶氨基霉素的组成成分，通过分子内嘧啶传递法以立体选择性方式合成。用糖基氟化物对4'-位进行进一步糖基化得到胞嘧啶氨基霉素的二糖核苷骨架。
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