Stemmermann G N, Goodman M T, Nomura A M
Japan-Hawaii Cancer Study, Kuakini Medical Center, Honolulu 96817.
Cancer. 1992 Dec 15;70(12):2766-71. doi: 10.1002/1097-0142(19921215)70:12<2766::aid-cncr2820701207>3.0.co;2-y.
Adenocarcinoma of the small intestine is uncommon. The Hawaii Tumor Registry (HTR) has identified 49 of these tumors since 1960, and the Japan-Hawaii Cancer Study (JHCS) has identified only four of these tumors among a cohort of 8006 Hawaiian-Japanese men followed up for a period of 22 years. Each of the four men reported by the JHCS had multicentric gastrointestinal cancers.
Newly diagnosed cancers are recorded separately by the HTR and JHCS, and linkage is maintained between the two files. Family histories are available from the JHCS, and these are supplemented by a state population file maintained by the Department of Genetics, University of Hawaii.
Five men, all Japanese, were found to have carcinoma of the proximal small intestine. Each had multicentric carcinomas of the gastrointestinal tract. Carcinoma of the stomach and colon was found in the primary relatives of each of four men whose families lived in Hawaii.
The familial clustering of uncommon neoplasms (small bowel carcinoma and multicentric large bowel carcinoma), and the concurrence of gastric and colonic carcinoma suggests that these subjects have a genetic trait that increases susceptibility to a broad range of carcinogens.
小肠腺癌并不常见。自1960年以来，夏威夷肿瘤登记处（HTR）已识别出49例此类肿瘤，而在一项对8006名夏威夷-日本男性进行了22年随访的队列研究中，日本-夏威夷癌症研究（JHCS）仅识别出4例此类肿瘤。JHCS报告的这4名男性均患有多中心性胃肠道癌症。
新诊断的癌症由HTR和JHCS分别记录，并且这两个档案之间保持关联。家族史可从JHCS获得，并且由夏威夷大学遗传学系维护的州人口档案对这些家族史进行补充。
发现5名男性，均为日本人，患有近端小肠癌。每个人都有多中心性胃肠道癌。在4名家族居住在夏威夷的男性的一级亲属中发现了胃癌和结肠癌。
罕见肿瘤（小肠癌和多中心性大肠癌）的家族聚集性，以及胃癌和结肠癌的并存表明，这些受试者具有一种遗传特征，使其对多种致癌物的易感性增加。
