Boules Mona, Fredrickson Paul, Richelson Elliott
Neuropsychopharmacology Laboratory, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
Life Sci. 2003 Oct 17;73(22):2785-92. doi: 10.1016/s0024-3205(03)00674-x.
Neurotensin (NT) is a neuropeptide found in the central nervous system and gastrointestinal tract. It is closely associated with dopaminergic and other neurotransmitter systems, and evidence supports a role for NT in various neuropsychiatric disorders. Because NT is readily degraded by peptidases, our group has developed various NT agonists that can be injected systemically, cross the blood brain barrier (BBB), yet retain the characteristics of native NT. The most widely studied and successful of these compounds, called NT69L, holds promise as a therapeutic agent for Parkinson's disease, schizophrenia, psychostimulant abuse and nicotine dependence, and serves as a tool to study the cellular and molecular effects of NT.
神经降压素（NT）是一种在中枢神经系统和胃肠道中发现的神经肽。它与多巴胺能及其他神经递质系统密切相关，有证据支持NT在各种神经精神疾病中发挥作用。由于NT很容易被肽酶降解，我们团队已开发出多种可全身注射、能穿过血脑屏障（BBB）且保留天然NT特性的NT激动剂。这些化合物中研究最广泛且最成功的一种，称为NT69L，有望成为治疗帕金森病、精神分裂症、精神兴奋剂滥用和尼古丁依赖的药物，并可作为研究NT细胞和分子效应的工具。
