Neuropsychopharmacology Laboratory, Department of Neuroscience, Mayo Clinic Florida Jacksonville, FL, USA.
Front Endocrinol (Lausanne). 2013 Mar 22;4:36. doi: 10.3389/fendo.2013.00036. eCollection 2013.
Neurotensin (NT) is a tridecapeptide that is found in the central nervous system (CNS) and the gastrointestinal tract. NT behaves as a neurotransmitter in the brain and as a hormone in the gut. Additionally, NT acts as a neuromodulator to several neurotransmitter systems including dopaminergic, sertonergic, GABAergic, glutamatergic, and cholinergic systems. Due to its association with such a wide variety of neurotransmitters, NT has been implicated in the pathophysiology of several CNS disorders such as schizophrenia, drug abuse, Parkinson's disease (PD), pain, central control of blood pressure, eating disorders, as well as, cancer and inflammation. The present review will focus on the role that NT and its analogs play in schizophrenia, endocrine function, pain, psychostimulant abuse, and PD.
神经降压素（NT）是一种存在于中枢神经系统（CNS）和胃肠道中的十三肽。NT 在大脑中充当神经递质，在肠道中充当激素。此外，NT 作为神经调质作用于多种神经递质系统，包括多巴胺能、血清素能、GABA 能、谷氨酸能和胆碱能系统。由于其与如此多种类的神经递质相关，NT 已被牵连到几种 CNS 疾病的病理生理学中，如精神分裂症、药物滥用、帕金森病（PD）、疼痛、血压的中枢控制、饮食失调以及癌症和炎症。本综述将重点介绍 NT 及其类似物在精神分裂症、内分泌功能、疼痛、精神兴奋剂滥用和 PD 中的作用。
