Sengun Ihsan S, Appel Stanley H
Department of Neurology, Medical School, Dokuz Eylul University, Balcova, Izmir 35340, Turkey.
J Neuroimmunol. 2003 Sep;142(1-2):137-40. doi: 10.1016/s0165-5728(03)00263-7.
In this study, the levels of anti-Fas antibodies were evaluated in patients with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Sera from 25% of patients with sporadic ALS (sALS) and 22% of patients with familial ALS (fALS) contained abnormal levels of anti-Fas antibodies compared with normal controls. Half of patients with Parkinson's disease (PD), but no patients with Alzheimer's disease (AD), had abnormal levels of anti-Fas antibodies. There was no correlation between the antibody levels of patients with ALS and the length or stage of their disease. These data demonstrate that the peripheral immune system is activated as reflected by anti-Fas antibodies in ALS, but this activation is not specific to ALS.
在本研究中，对肌萎缩侧索硬化症（ALS）患者和其他神经退行性疾病患者的抗Fas抗体水平进行了评估。与正常对照组相比，25%的散发性ALS（sALS）患者和22%的家族性ALS（fALS）患者血清中抗Fas抗体水平异常。帕金森病（PD）患者中有一半抗Fas抗体水平异常，但阿尔茨海默病（AD）患者中没有。ALS患者的抗体水平与其疾病的病程或阶段之间没有相关性。这些数据表明，ALS患者外周免疫系统被抗Fas抗体激活，但这种激活并非ALS所特有。
