Liu Shen, Hong Ye, Wang Bian-Rong, Wei Zi-Qiao, Zhao Hong-Dong, Jiang Teng, Zhang Ying-Dong, Shi Jian-Quan
Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, 210006, PR China.
Department of Neurology, Geriatric Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210006, PR China.
Neurol Sci. 2024 Sep;45(9):4133-4149. doi: 10.1007/s10072-024-07581-x. Epub 2024 May 11.
Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative disease, which is characterized by the selective loss of the upper and lower motor neurons. The pathogenesis of ALS remains to be elucidated and has been connected to genetic, environmental and immune conditions. Evidence from clinical and experimental studies has suggested that the immune system played an important role in ALS pathophysiology. Autoantibodies are essential components of the immune system. Several autoantibodies directed at antigens associated with ALS pathogenesis have been identified in the serum and/or cerebrospinal fluid of ALS patients. The aim of this review is to summarize the presence and clinical significance of autoantibodies in ALS.
肌萎缩侧索硬化症（ALS）是一种使人衰弱且迅速致命的神经退行性疾病，其特征是上下运动神经元的选择性丧失。ALS的发病机制仍有待阐明，并且与遗传、环境和免疫状况有关。临床和实验研究的证据表明，免疫系统在ALS病理生理学中起重要作用。自身抗体是免疫系统的重要组成部分。在ALS患者的血清和/或脑脊液中已鉴定出几种针对与ALS发病机制相关抗原的自身抗体。本综述的目的是总结ALS中自身抗体的存在情况及其临床意义。
