硬膜外吗啡可降低人体中氟烷的最低肺泡有效浓度。
Epidural morphine reduces halothane MAC in humans.
作者信息
Schwieger I M, Klopfenstein C E, Forster A
机构信息
Département D'Anesthesiologie, Hôpital Cantonal Universitaire, Genève, Suisse.
出版信息
Can J Anaesth. 1992 Nov;39(9):911-4. doi: 10.1007/BF03008338.
The effect of epidural morphine sulphate (4 mg in 10 ml saline) on the minimum alveolar concentration of halothane was investigated in a double-blind, randomized fashion in ten adult patients undergoing abdominal surgery, and compared with the minimum alveolar concentration of halothane after epidural administration of 10 ml saline in a similar group of patients. Morphine sulphate, administered through the epidural catheter 98 +/- 33 min before to skin incision reduced the minimum alveolar concentration of halothane by 28% (0.57% vs 0.78%, P < 0.05).
在十名接受腹部手术的成年患者中，以双盲、随机的方式研究了硬膜外注射硫酸吗啡（10毫升生理盐水中含4毫克）对氟烷最低肺泡浓度的影响，并与在一组类似患者中硬膜外注射10毫升生理盐水后氟烷的最低肺泡浓度进行了比较。在皮肤切开前98±33分钟通过硬膜外导管给予硫酸吗啡，使氟烷的最低肺泡浓度降低了28%（从0.78%降至0.57%，P<0.05）。
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