Serbina Natalya V, Pamer Eric G
Diseases Service and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Science. 2003 Sep 26;301(5641):1856-7. doi: 10.1126/science.1090613.
Dendritic cells in the skin, called Langerhans cells, are the obvious candidates for transporting antigen from the epidermis to the lymph nodes and for activating T cell defense. However, as Serbina and Pamer discuss in their Perspective, at least in the case of viral antigens, it seems that other dendritic cell subsets residing in the dermis are the most important players in T cell-mediated defense against viral infection of the skin.
皮肤中的树突状细胞,即朗格汉斯细胞,显然是将抗原从表皮运输到淋巴结并激活T细胞防御的候选者。然而,正如塞尔比纳和帕默在他们的观点文章中所讨论的,至少在病毒抗原的情况下,似乎驻留在真皮中的其他树突状细胞亚群才是T细胞介导的皮肤病毒感染防御中最重要的参与者。