外周T细胞耐受性和免疫中迁移性树突状细胞与淋巴结驻留树突状细胞之间的抗原传递

Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity.

作者信息

Carbone Francis R, Belz Gabrielle T, Heath William R

机构信息

The Department of Microbiology and Immunology, The University of Melbourne, Parkville 3010, Victoria, Australia.

出版信息

Trends Immunol. 2004 Dec;25(12):655-8. doi: 10.1016/j.it.2004.09.013.

DOI:10.1016/j.it.2004.09.013

PMID:15530835

Abstract

Dendritic cells (DCs) consist of a heterogeneous collection of subsets, many with unique phenotypic and functional characteristics. Although certain subsets migrate from peripheral non-lymphoid tissues, there is evidence that antigen presentation can extend to DCs that permanently reside within the lymph node. This Opinion describes this finding in the context of antigen transfer between migrating and lymphoid-resident DCs in cases of T-cell priming and tolerance induction.

摘要

树突状细胞（DCs）由多种异质性亚群组成，其中许多具有独特的表型和功能特征。尽管某些亚群从外周非淋巴组织迁移而来，但有证据表明抗原呈递可扩展至永久驻留在淋巴结内的DCs。本观点在T细胞致敏和耐受诱导情况下，就迁移性DCs与驻留于淋巴组织的DCs之间的抗原转移背景下描述了这一发现。