Smyth Matthew D, Tubbs R Shane, Wellons John C, Oakes W Jerry, Blount Jeffrey P, Grabb Paul A
Pediatric Neurosurgery, Children's Hospital of Alabama, Birmingham, AL 35233, USA.
Pediatr Neurosurg. 2003 Nov;39(5):258-63. doi: 10.1159/000072871.
We review our experience of endoscopic third ventriculocisternostomy (ETV) in children with hydrocephalus from central nervous system (CNS) infection or intraventricular hemorrhage to better elucidate success rates and predictors of success in these children.
We performed a retrospective review of 12 children less than 21 years of age with ETV treated from 1999 to 2002 with a minimum follow-up of 12 months. Children selected for surgery had been diagnosed with hydrocephalus from perinatal germinal matrix hemorrhage or CNS infection and had neuroimaging consistent with obstruction of the aqueduct, fourth ventricular outlets or both at the time of ETV. Charts and imaging studies were reviewed to determine clinical outcomes and predictors of successful ETV. An ETV was deemed successful if the child did not require placement or replacement of a ventriculoperitoneal shunt.
Thirteen ETV were performed in 12 patients (7 boys and 5 girls; mean age 9.2 years, range 3.8-21 years), with an overall success rate of 60% for those with CNS infections and 71% for those with perinatal intraventricular hemorrhage at initial presentation. There were no significant complications from the procedure.
ETV is a safe procedure, which in carefully selected children with etiologies of hydrocephalus thought to be 'communicating' in nature carries a satisfyingly high success rate. Further application and study of this modality in larger groups of patients with these causes of hydrocephalus is warranted.
我们回顾了内镜下第三脑室造瘘术(ETV)治疗中枢神经系统(CNS)感染或脑室内出血所致脑积水患儿的经验,以更好地阐明这些患儿的成功率及成功的预测因素。
我们对1999年至2002年接受ETV治疗的12例21岁以下儿童进行了回顾性研究,最小随访时间为12个月。入选手术的儿童被诊断为围生期生发基质出血或CNS感染所致脑积水,且在ETV时神经影像学检查结果与中脑导水管、第四脑室出口或两者均梗阻相符。查阅病历和影像学研究以确定ETV成功的临床结局及预测因素。若患儿无需置入或更换脑室腹腔分流管,则认为ETV成功。
12例患者(7例男孩,5例女孩;平均年龄9.2岁,范围3.8 - 21岁)共接受了13次ETV手术,初次就诊时,CNS感染患儿的总体成功率为60%,围生期脑室内出血患儿的总体成功率为71%。该手术无明显并发症。
ETV是一种安全的手术,对于精心挑选的、病因被认为本质上是“交通性”脑积水的患儿,其成功率令人满意地高。有必要在更多此类脑积水病因的患者群体中进一步应用和研究这种治疗方式。