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内镜下第三脑室造瘘术在结核性脑积水治疗中的应用。

Use of endoscopic third ventriculostomy in hydrocephalus of tubercular origin.

作者信息

Bhagwati Sanat, Mehta Nirav, Shah Suneel

机构信息

Department of Neurosurgery, Bombay Hospital Institute of Medical Sciences, Mumbai, India.

出版信息

Childs Nerv Syst. 2010 Dec;26(12):1675-82. doi: 10.1007/s00381-010-1183-1. Epub 2010 May 28.

Abstract

PURPOSE

The purpose of this paper was to study the feasibility of endoscopic third ventriculostomy (ETV) as a treatment modality in patients with hydrocephalus of tubercular origin.

MATERIALS AND METHODS

Literature on ETV in hydrocephalus of tubercular origin has been reviewed, and we have gathered experiences of neurosurgeons from various institutions in our country practicing ETV.

RESULTS

Hydrocephalus, a common complication of tubercular meningitis, may be of communicating type or of obstructive variety. The communicating type is treated by medical therapy in 70-92% cases, whereas the obstructive type requires surgical intervention. The outcome of surgery depends upon gradation of disease. Shunting however has been a nightmare for neurosurgeons treating such patients (Smyth et al., Pediatr Neurosurg 39: 258-263, 2003). The shunts tend to get blocked with debris. Having found ETV as a successful modality of treatment in obstructive hydrocephalus of other etiology, neurosurgeons have attempted it in hydrocephalus of tubercular origin. Though various authors have had a success rate of 65-68%, failure has been quite high in acute cases due to thickening of the floor of third ventricle and distorted anatomy. The success rate is higher in chronic and burnt out cases.

CONCLUSION

Tubercular meningitic hydrocephalus is difficult to treat endoscopically as compared with other forms of meningitic hydrocephalus and requires adequate expertise and experience, especially in acute cases. Therefore, one would be justified in avoiding the use of ETV in acute cases and wait till patient presents with a failed shunt. Use of ETV in subacute and chronic cases seems to be justified as the first line of treatment.

摘要

目的

本文旨在研究内镜下第三脑室造瘘术(ETV)作为结核性脑积水患者治疗方式的可行性。

材料与方法

回顾了关于结核性脑积水行ETV的文献,并收集了我国各机构实施ETV的神经外科医生的经验。

结果

脑积水是结核性脑膜炎的常见并发症,可为交通性或梗阻性。70% - 92%的交通性脑积水病例采用药物治疗,而梗阻性脑积水则需要手术干预。手术结果取决于疾病的分级。然而,分流术一直是治疗此类患者的神经外科医生的噩梦(Smyth等人,《小儿神经外科》39: 258 - 263,2003)。分流管容易被碎屑堵塞。鉴于ETV在其他病因的梗阻性脑积水中是一种成功的治疗方式,神经外科医生已尝试将其用于结核性脑积水。尽管不同作者的成功率为65% - 68%,但由于第三脑室底部增厚和解剖结构扭曲,急性病例的失败率相当高。慢性和病情稳定的病例成功率更高。

结论

与其他形式的脑膜炎性脑积水相比,结核性脑膜炎性脑积水在内镜下治疗困难,需要足够的专业知识和经验,尤其是在急性病例中。因此,在急性病例中避免使用ETV并等待患者分流失败是合理的。在亚急性和慢性病例中使用ETV作为一线治疗似乎是合理的。

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