Brocard F, Clarac F, Vinay L
Institut de Neurosciences Physiologiques et Cognitives, CNRS, 31 chemin Joseph Aiguier, 13402 Marseille Cx 20, France.
Neuroreport. 2003 Sep 15;14(13):1697-700. doi: 10.1097/00001756-200309150-00008.
We investigated the influence of gravity on the maturation of electrical properties of lumbar motoneurons and the development of their inputs from ventral descending pathways, which are important for the control of posture and locomotion. Using electrophysiological approaches in the in vitro brain stem-spinal cord preparation of neonatal rats born and reared in hypergravity field we demonstrate that: (1) the postnatal development of descending inputs to lumbar enlargement was reduced in animals submitted to hypergravity; (2) similar developmental pattern of basic electrical properties observed between motoneurons of hypergravity and control animals could not account for the changes in descending inputs. We concluded that gravity was critical to shape development of the supraspinal afferents in the lumbar spinal cord throughout the postnatal period.
我们研究了重力对腰段运动神经元电特性成熟以及来自腹侧下行通路的输入发育的影响，这些对于姿势和运动控制很重要。在出生并饲养于超重力场的新生大鼠的体外脑干 - 脊髓标本中使用电生理方法，我们证明：（1）处于超重力环境的动物中，腰膨大下行输入的产后发育减少；（2）超重力动物和对照动物的运动神经元之间观察到的基本电特性的相似发育模式不能解释下行输入的变化。我们得出结论，重力对于整个产后时期腰段脊髓中脊髓上传入神经的发育形成至关重要。
