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[原发性膀胱输尿管反流患儿的肾瘢痕]

[Renal scars in children with primary vesicoureteral reflux].

作者信息

Macedo Célia S, Riyuzo Márcia C, Bastos Herculano D

机构信息

Departamento de Pediatria, Faculdade de Medicina, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.

出版信息

J Pediatr (Rio J). 2003 Jul-Aug;79(4):355-62.

Abstract

OBJECTIVE

To determine the incidence of renal scars in children with primary vesicoureteral reflux taking into consideration the following variables: sex, age at diagnosis, febrile urinary infection, degree of reflux and bacteria specimen.

METHOD

Retrospective study of 58 children with age ranging from 2 months to 11 years, presenting primary vesicoureteral reflux detected by voiding cystourethrogram after documented episode of urinary tract infection. The diagnosis of renal scarring was obtained by dimercaptosuccinic acid scan 5 months after the treatment of the urinary infection; in 40 children the dimercaptosuccinic acid scan was performed again from 6 months up to 6 years after the treatment.

RESULTS

45 children (77.6%) were girls and 13 (22.4%) were boys, 51.7% were 2 years old or younger. The incidence of renal scarring was 55.2%. There was significant higher proportion of renal scars in girls, when the patients presented fever and dilated vesicoureteral reflux (III, IV, V). Fever and female sex were risk factors for the development of renal scars (fever--ODDS ratio=6.19 and female sex--ODDS ratio=4.12). There was a prevalence of renal scars in children over 2 years old. The interval between the beginning of the symptoms and the first medical visit was longer in the children with renal scars. New renal scars were observed in 12.5%.

CONCLUSIONS

Fever and female sex were risk factors for the presence of renal scars, mainly in the dilated vesicoureteral reflux. The high incidence of renal scars in this study may be related to delayed diagnosis of vesicoureteral reflux.

摘要

目的

考虑以下变量,确定原发性膀胱输尿管反流患儿肾瘢痕的发生率:性别、诊断时年龄、发热性泌尿道感染、反流程度和细菌标本。

方法

对58例年龄在2个月至11岁之间的儿童进行回顾性研究,这些儿童在记录有尿路感染发作后经排尿膀胱尿道造影检测出原发性膀胱输尿管反流。在尿路感染治疗5个月后通过二巯基丁二酸扫描获得肾瘢痕诊断;40名儿童在治疗后6个月至6年再次进行二巯基丁二酸扫描。

结果

45名儿童(77.6%)为女孩,13名(22.4%)为男孩,51.7%的儿童年龄在2岁及以下。肾瘢痕的发生率为55.2%。当患者出现发热和膀胱输尿管反流扩张(III、IV、V级)时,女孩中肾瘢痕的比例显著更高。发热和女性性别是肾瘢痕形成的危险因素(发热——优势比=6.19,女性性别——优势比=4.12)。2岁以上儿童中肾瘢痕更为普遍。有肾瘢痕的儿童从症状开始到首次就诊的间隔时间更长。观察到12.5%的患儿出现新的肾瘢痕。

结论

发热和女性性别是肾瘢痕存在的危险因素,主要见于膀胱输尿管反流扩张的情况。本研究中肾瘢痕的高发生率可能与膀胱输尿管反流的诊断延迟有关。

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