Björnsson Asgeir, Gudmundsson Grétar, Gudfinnsson Einar, Hrafnsdóttir María, Benedikz John, Skúladóttir Svanhildur, Kristjánsson Kristleifur, Frigge Michael L, Kong Augustine, Stefánsson Kári, Gulcher Jeffrey R
deCODE Genetics, Reykjavik, Iceland.
Am J Hum Genet. 2003 Nov;73(5):986-93. doi: 10.1086/378417. Epub 2003 Sep 25.
Migraine is a common form of headache and has a significant genetic component. Here, we report linkage results from a study in Iceland of migraine without aura (MO). The study group comprised patients with migraine recruited by neurologists and from the registry of the Icelandic Migraine Society, as well as through the use of a questionnaire sent to a random sample of 20,000 Icelanders. Migraine diagnoses were made and confirmed using diagnostic criteria established by the International Headache Society. A genome-wide scan with multipoint allele-sharing methods was performed on 289 patients suffering from MO. Linkage was observed to a locus on chromosome 4q21 (LOD=2.05; P=.001). The locus reported here overlaps a locus (MGR1) reported elsewhere for patients with migraine with aura (MA) in the Finnish population. This replication of the MGR1 locus in families with MO indicates that the gene we have mapped may contribute to both MA and MO. Further analysis indicates that the linkage evidence improves for affected females and, especially, with a slightly relaxed definition of MO (LOD=4.08; P=7.2 x 10(-6)).
偏头痛是一种常见的头痛形式，具有显著的遗传成分。在此，我们报告了冰岛一项无先兆偏头痛（MO）研究的连锁分析结果。研究组包括由神经科医生招募的偏头痛患者、冰岛偏头痛协会登记在册的患者，以及通过向20000名冰岛人随机样本发送问卷招募的患者。偏头痛诊断采用国际头痛协会制定的诊断标准进行并确认。对289例MO患者进行了全基因组扫描，并采用多点等位基因共享方法。在4号染色体q21位点观察到连锁（LOD=2.05；P=.001）。此处报告的位点与芬兰人群中先兆偏头痛（MA）患者在其他地方报告的一个位点（MGR1）重叠。在MO家族中MGR1位点的这种复制表明，我们定位的基因可能对MA和MO都有影响。进一步分析表明，对于受影响的女性，尤其是对MO定义稍有放宽时，连锁证据得到增强（LOD=4.08；P=7.2×10⁻⁶）。
