Fang Zeqiang, Li Huizeng, Wang Changyong
Department of Stomatology and Maxillofacial Surgery, Stomatological College, Fourth Military Medical University, Xi'an 710032, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2003 Aug;21(4):274-6.
To study telomerase activity and expression of oncogenes c-myc and p53 in tongue cancer, analyse the interaction among them, and assess their possible correlations with tongue cancer clinicopathological features.
To detective the telomerase activity by TRAP and examine the positive expression of c-myc and p53 in tongue cancer by hybridization in situ.
A high telomerase activity existed in lower differentiated tongue cancer (P < 0.05); the positive expression of c-myc increased significantly in lower grade tongue cancer (P < 0.05) and the positive expression of p53 decreased increasingly in tongue cancer accompanied with lymph node metastasis (P < 0.05).
Telomerase may play a key role in the tumorigenesis of tongue cancer. Meantime, c-myc and p53 exerts important effect on telomerase activation during the course of tongue cancer generation and development.
研究端粒酶活性及癌基因c-myc和p53在舌癌中的表达，分析它们之间的相互作用，并评估其与舌癌临床病理特征的可能相关性。
采用端粒重复序列扩增法（TRAP）检测端粒酶活性，原位杂交法检测舌癌中c-myc和p53的阳性表达。
低分化舌癌中端粒酶活性较高（P < 0.05）；低级别舌癌中c-myc阳性表达显著增加（P < 0.05），伴有淋巴结转移的舌癌中p53阳性表达逐渐降低（P < 0.05）。
端粒酶可能在舌癌的发生中起关键作用。同时，c-myc和p53在舌癌发生发展过程中对端粒酶激活发挥重要作用。
