Li Yan, Xu Pu, Zhang Ping-An, Su Han-Wen, Zhang Jie
Department of Clinical Laboratory Science, Renmin Hospital, Wuhan University, Wuhan, Hubei 430060, China.
Zhonghua Nan Ke Xue. 2003 Aug;9(5):361-3, 366.
To analyze the stability of different serum prostate-specific antigens (PSA) in patients with benign prostatic hyperplasia (BPH), and investigate their application value in the diagnosis of prostate disease.
One hundred and five patients with BPH were divided into 3 groups by their total PSA (tPSA) level, 67 in group A (tPSA < 4 micrograms/L), 26 in group B (4 micrograms/L < or = tPSA < or = 10 micrograms/L) and 12 in group C (tPSA > 10 micrograms/L). These patients were also divided into another 3 groups by age, 18 in group a (< or = 55 years old), 33 in group b (from 56 to 69 years old) and 54 in group c (> or = 70 years old). tPSA, free PSA (fPSA) and complexed PSA (cPSA) were measured by magnetism-particulate-immuno-chemistry luminescence method, the ratios of cPSA/tPSA, fPSA/tPSA, fPSA/cPSA were calculated in 105 patients with BPH, and their stabilities were compared in different tPSA level and age groups.
The ratios of cPSA/tPSA, fPSA/tPSA and fPSA/cPSA were steadier than other PSAs in different tPSA level and age groups with BPH.
The ratios of cPSA/tPSA, fPSA/tPSA and fPSA/cPSA probably have more application value in the diagnosis of prostate disease.
分析良性前列腺增生（BPH）患者不同血清前列腺特异性抗原（PSA）的稳定性，并探讨其在前列腺疾病诊断中的应用价值。
105例BPH患者按总PSA（tPSA）水平分为3组，A组67例（tPSA＜4μg/L），B组26例（4μg/L≤tPSA≤10μg/L），C组12例（tPSA＞10μg/L）。这些患者又按年龄分为3组，a组18例（≤55岁），b组33例（56～69岁），c组54例（≥70岁）。采用磁性微粒免疫化学发光法检测tPSA、游离PSA（fPSA）和复合PSA（cPSA），计算105例BPH患者的cPSA/tPSA、fPSA/tPSA、fPSA/cPSA比值，并比较其在不同tPSA水平和年龄组中的稳定性。
在不同tPSA水平和年龄组的BPH患者中，cPSA/tPSA、fPSA/tPSA和fPSA/cPSA比值比其他PSA更稳定。
cPSA/tPSA、fPSA/tPSA和fPSA/cPSA比值在前列腺疾病诊断中可能具有更大的应用价值。
