[智利患者中B型和F型人类免疫缺陷病毒亚型的鉴定]
[Identification of B and F human immunodeficiency virus subtypes in Chilean patients].
作者信息
Ríos Maritza, Villanueva Carola, San Martín Carolina, Ramírez Eugenio
机构信息
Centro Nacional de Referencia del SIDA, Subdepartamento Virología, Instituto de Salud Pública de Chile, Santiago.
出版信息
Rev Med Chil. 2003 Jul;131(7):711-8.
BACKGROUND
Type I human immunodeficiency virus (HIV) is characterized by a great genetic variability. There are three groups of virus throughout the world: O, N and M. Group M is responsible for AIDS pandemic and is subdivided in 9 genetic subtypes. Most viral strains in South America are subtype B.
AIM
To determine the frequency of HIV subtypes in Chilean patients.
MATERIAL AND METHODS
Genetic analysis of C2-V3-C3 region of the gene env in HIV strains coming from 77 Chilean subjects infected by different means. DNA heteroduplex mobility assay was used to determine HIV subtypes.
RESULTS
Sixty eight cases were infected with subtype B (88.3%) and nine cases were infected with subtype F (11.7%).
CONCLUSIONS
Subtype B is the predominant HIV in Chile, but subtype F is also present.
背景
I型人类免疫缺陷病毒（HIV）具有高度的基因变异性。全球有三组病毒：O组、N组和M组。M组导致了艾滋病大流行，并细分为9个基因亚型。南美洲的大多数病毒株是B亚型。
目的
确定智利患者中HIV亚型的频率。
材料与方法
对来自77名通过不同途径感染的智利受试者的HIV毒株的env基因C2-V3-C3区域进行基因分析。采用DNA异源双链迁移率分析法确定HIV亚型。
结果
68例感染B亚型（88.3%），9例感染F亚型（11.7%）。
结论
B亚型是智利主要的HIV亚型，但F亚型也存在。
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