延髓头端腹外侧区C1神经元与心血管调节
Rostral ventrolateral medulla C1 neurons and cardiovascular regulation.
作者信息
Madden Christopher J, Sved Alan F
机构信息
Department of Neuroscience, 446 Crawford Hall, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
出版信息
Cell Mol Neurobiol. 2003 Oct;23(4-5):739-49. doi: 10.1023/a:1025000919468.
Abstract
- The rostral ventrolateral medulla (RVLM) is essential for the normal control of arterial pressure. This region of the brainstem is heterogeneous, and contains spinally projecting neurons that contain phenylethanolamine-N-methyltransferase (C1 neurons) and non-C1 neurons. 2. The availability of a toxin, a dopamine-beta-hydroxylase antibody conjugated to saporin, that can selectively destroy C1 neurons within the RVLM allows for the study of cardiovascular regulation in rats following depletion of the C1 neuronal population. 3. C1 neurons are not essential for the maintenance of resting blood pressure in anesthetized rats, but do contribute to many cardiovascular responses mediated through the RVLM. 4. The depressor response elicited by clonidine injected into the RVLM is dependent upon C1 neurons. 5. Studies in rats with selective toxin-induced destruction of RVLM C1 neurons demonstrate that C1 neurons contribute importantly to cardiovascular regulation.
摘要
- 延髓头端腹外侧区（RVLM）对动脉血压的正常控制至关重要。脑干的这个区域具有异质性，包含向脊髓投射的神经元，这些神经元含有苯乙醇胺 - N - 甲基转移酶（C1神经元）和非C1神经元。2. 有一种毒素，即与皂草素偶联的多巴胺 - β - 羟化酶抗体，它能够选择性地破坏RVLM内的C1神经元，这使得在C1神经元群体耗竭后对大鼠心血管调节进行研究成为可能。3. C1神经元对于麻醉大鼠静息血压的维持并非必不可少，但确实对许多通过RVLM介导的心血管反应有贡献。4. 向RVLM注射可乐定引发的降压反应依赖于C1神经元。5. 对选择性毒素诱导破坏RVLM C1神经元的大鼠的研究表明，C1神经元对心血管调节起着重要作用。
相似文献
1
Rostral ventrolateral medulla C1 neurons and cardiovascular regulation.延髓头端腹外侧区C1神经元与心血管调节
Cell Mol Neurobiol. 2003 Oct;23(4-5):739-49. doi: 10.1023/a:1025000919468.
2
Regulation of sympathetic tone and arterial pressure by the rostral ventrolateral medulla after depletion of C1 cells in rats.大鼠C1细胞耗竭后延髓头端腹外侧核对交感神经张力和动脉血压的调节
Ann N Y Acad Sci. 2001 Jun;940:259-69. doi: 10.1111/j.1749-6632.2001.tb03682.x.
3
Cardiovascular regulation after destruction of the C1 cell group of the rostral ventrolateral medulla in rats.大鼠延髓头端腹外侧C1细胞群破坏后的心血管调节
Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2734-48. doi: 10.1152/ajpheart.00155.2003. Epub 2003 Aug 21.
4
Lesions of the C1 catecholaminergic neurons of the ventrolateral medulla in rats using anti-DbetaH-saporin.使用抗多巴胺β-羟化酶-皂草素损毁大鼠延髓腹外侧C1儿茶酚胺能神经元
Am J Physiol. 1999 Oct;277(4):R1063-75. doi: 10.1152/ajpregu.1999.277.4.R1063.
5
Regulation of sympathetic tone and arterial pressure by rostral ventrolateral medulla after depletion of C1 cells in rat.大鼠C1细胞耗竭后延髓头端腹外侧核对交感神经张力和动脉血压的调节
J Physiol. 2000 Nov 15;529 Pt 1(Pt 1):221-36. doi: 10.1111/j.1469-7793.2000.00221.x.
6
Preproenkephalin mRNA is expressed by C1 and non-C1 barosensitive bulbospinal neurons in the rostral ventrolateral medulla of the rat.前脑啡肽原mRNA在大鼠延髓头端腹外侧区的C1和非C1压力敏感延髓脊髓神经元中表达。
J Comp Neurol. 2001 Jun 18;435(1):111-26. doi: 10.1002/cne.1196.
7
Glutamate transmission in the rostral ventrolateral medullary sympathetic premotor pathway.延髓头端腹外侧交感神经运动前通路中的谷氨酸传递
Cell Mol Neurobiol. 2003 Oct;23(4-5):761-72. doi: 10.1023/a:1025005020376.
8
Quantitative analysis of spinally projecting adrenaline-synthesising neurons of C1, C2 and C3 groups in rat medulla oblongata.大鼠延髓中C1、C2和C3组脊髓投射肾上腺素合成神经元的定量分析。
J Auton Nerv Syst. 1990 Jul;30(3):209-20. doi: 10.1016/0165-1838(90)90252-e.
9
Modulatory inputs on sympathetic neurons in the rostral ventrolateral medulla in the rat.大鼠延髓头端腹外侧区交感神经元的调制性输入
Cell Mol Neurobiol. 2003 Oct;23(4-5):665-80. doi: 10.1023/a:1025040600812.
10
Selective C1 Lesioning Slightly Decreases Angiotensin II Type I Receptor Expression in the Rat Rostral Ventrolateral Medulla (RVLM).选择性C1损伤会轻微降低大鼠延髓头端腹外侧区（RVLM）中血管紧张素II 1型受体的表达。
Neurochem Res. 2015 Oct;40(10):2113-20. doi: 10.1007/s11064-015-1649-3. Epub 2015 Jul 3.
引用本文的文献
1
Infralimbic prefrontal cortical projections to the autonomic brainstem: quantification of inputs to cholinergic and adrenergic/noradrenergic nuclei.边缘下前额叶皮质向自主脑干的投射：对胆碱能和肾上腺素能/去甲肾上腺素能核团输入的定量分析。
Brain Struct Funct. 2025 Jul 10;230(7):117. doi: 10.1007/s00429-025-02983-9.
2
Mapping of afferent and efferent connections of phenylethanolamine N-methyltransferase-expressing neurons in the nucleus tractus solitarii.孤束核中表达苯乙醇胺 N-甲基转移酶的神经元的传入和传出连接的定位。
CNS Neurosci Ther. 2024 Jun;30(6):e14808. doi: 10.1111/cns.14808.
3
SGLT2 and SGLT1 inhibitors suppress the activities of the RVLM neurons in newborn Wistar rats.SGLT2 和 SGLT1 抑制剂可抑制新生 Wistar 大鼠 RVLM 神经元的活性。
Hypertens Res. 2024 Jan;47(1):46-54. doi: 10.1038/s41440-023-01417-5. Epub 2023 Sep 15.
4
The Rostral Ventromedial and Lateral Medulla Are the Major Areas Responsive to Lung Cancer Progression among Brainstem Lung-Innervating Nuclei.延髓腹内侧吻侧和外侧是脑干肺神经支配核中对肺癌进展有反应的主要区域。
Brain Sci. 2022 Nov 2;12(11):1486. doi: 10.3390/brainsci12111486.
5
Responses of neurons in the rostral ventrolateral medulla of conscious cats to anticipated and passive movements.清醒猫延髓腹外侧头端区神经元对预期和被动运动的反应。
Am J Physiol Regul Integr Comp Physiol. 2020 Mar 1;318(3):R481-R492. doi: 10.1152/ajpregu.00205.2019. Epub 2020 Jan 15.
6
The Impact of Uremic Toxins on Cerebrovascular and Cognitive Disorders.尿毒症毒素对脑血管和认知障碍的影响。
Toxins (Basel). 2018 Jul 22;10(7):303. doi: 10.3390/toxins10070303.
7
Erythropoietin, a putative neurotransmitter during hypoxia, is produced in RVLM neurons and activates them in neonatal Wistar rats.促红细胞生成素是一种在缺氧时可能起神经递质作用的物质，在新生Wistar大鼠的延髓头端腹外侧区（RVLM）神经元中产生并激活这些神经元。
Am J Physiol Regul Integr Comp Physiol. 2018 May 1;314(5):R700-R708. doi: 10.1152/ajpregu.00455.2017. Epub 2018 Feb 14.
8
Systematic Morphometry of Catecholamine Nuclei in the Brainstem.脑干中儿茶酚胺核团的系统形态学研究
Front Neuroanat. 2017 Nov 2;11:98. doi: 10.3389/fnana.2017.00098. eCollection 2017.
9
Restoration of Rostral Ventrolateral Medulla Cystathionine- Lyase Activity Underlies Moxonidine-Evoked Neuroprotection and Sympathoinhibition in Diabetic Rats.还原延髓腹外侧前部胱硫醚-γ-裂解酶活性可介导莫索尼定诱导的糖尿病大鼠神经保护和交感神经抑制作用。
J Pharmacol Exp Ther. 2018 Feb;364(2):170-178. doi: 10.1124/jpet.117.243865. Epub 2017 Nov 13.
10
Does the sympathetic nervous system contribute to the pathophysiology of metabolic syndrome?交感神经系统是否参与代谢综合征的病理生理过程？
Front Physiol. 2015 Aug 25;6:234. doi: 10.3389/fphys.2015.00234. eCollection 2015.
Zotero 插件