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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Madden Christopher J, Sved Alan F

Department of Neuroscience, 446 Crawford Hall, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

Cell Mol Neurobiol. 2003 Oct;23(4-5):739-49. doi: 10.1023/a:1025000919468.

The rostral ventrolateral medulla (RVLM) is essential for the normal control of arterial pressure. This region of the brainstem is heterogeneous, and contains spinally projecting neurons that contain phenylethanolamine-N-methyltransferase (C1 neurons) and non-C1 neurons. 2. The availability of a toxin, a dopamine-beta-hydroxylase antibody conjugated to saporin, that can selectively destroy C1 neurons within the RVLM allows for the study of cardiovascular regulation in rats following depletion of the C1 neuronal population. 3. C1 neurons are not essential for the maintenance of resting blood pressure in anesthetized rats, but do contribute to many cardiovascular responses mediated through the RVLM. 4. The depressor response elicited by clonidine injected into the RVLM is dependent upon C1 neurons. 5. Studies in rats with selective toxin-induced destruction of RVLM C1 neurons demonstrate that C1 neurons contribute importantly to cardiovascular regulation.

延髓头端腹外侧区（RVLM）对动脉血压的正常控制至关重要。脑干的这个区域具有异质性，包含向脊髓投射的神经元，这些神经元含有苯乙醇胺 - N - 甲基转移酶（C1神经元）和非C1神经元。2. 有一种毒素，即与皂草素偶联的多巴胺 - β - 羟化酶抗体，它能够选择性地破坏RVLM内的C1神经元，这使得在C1神经元群体耗竭后对大鼠心血管调节进行研究成为可能。3. C1神经元对于麻醉大鼠静息血压的维持并非必不可少，但确实对许多通过RVLM介导的心血管反应有贡献。4. 向RVLM注射可乐定引发的降压反应依赖于C1神经元。5. 对选择性毒素诱导破坏RVLM C1神经元的大鼠的研究表明，C1神经元对心血管调节起着重要作用。

Madden Christopher J, Sved Alan F

Department of Neuroscience, 446 Crawford Hall, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

Cell Mol Neurobiol. 2003 Oct;23(4-5):739-49. doi: 10.1023/a:1025000919468.

The rostral ventrolateral medulla (RVLM) is essential for the normal control of arterial pressure. This region of the brainstem is heterogeneous, and contains spinally projecting neurons that contain phenylethanolamine-N-methyltransferase (C1 neurons) and non-C1 neurons. 2. The availability of a toxin, a dopamine-beta-hydroxylase antibody conjugated to saporin, that can selectively destroy C1 neurons within the RVLM allows for the study of cardiovascular regulation in rats following depletion of the C1 neuronal population. 3. C1 neurons are not essential for the maintenance of resting blood pressure in anesthetized rats, but do contribute to many cardiovascular responses mediated through the RVLM. 4. The depressor response elicited by clonidine injected into the RVLM is dependent upon C1 neurons. 5. Studies in rats with selective toxin-induced destruction of RVLM C1 neurons demonstrate that C1 neurons contribute importantly to cardiovascular regulation.

延髓头端腹外侧区（RVLM）对动脉血压的正常控制至关重要。脑干的这个区域具有异质性，包含向脊髓投射的神经元，这些神经元含有苯乙醇胺 - N - 甲基转移酶（C1神经元）和非C1神经元。2. 有一种毒素，即与皂草素偶联的多巴胺 - β - 羟化酶抗体，它能够选择性地破坏RVLM内的C1神经元，这使得在C1神经元群体耗竭后对大鼠心血管调节进行研究成为可能。3. C1神经元对于麻醉大鼠静息血压的维持并非必不可少，但确实对许多通过RVLM介导的心血管反应有贡献。4. 向RVLM注射可乐定引发的降压反应依赖于C1神经元。5. 对选择性毒素诱导破坏RVLM C1神经元的大鼠的研究表明，C1神经元对心血管调节起着重要作用。