儿童传染病严重程度与血清淀粉样蛋白A和C反应蛋白比值的相关性

Correlation between the severity of infectious diseases in children and the ratio of serum amyloid A protein and C-reactive protein.

作者信息

Huttunen Terhi, Teppo Anna-Maija, Lupisan Socorro, Ruutu Petri, Nohynek Hanna

机构信息

Department of Vaccines and Infectious Diseases Epidemiology, National Public Health Institute (KTL), Helsinki, Finland.

出版信息

Scand J Infect Dis. 2003;35(8):488-90. doi: 10.1080/00365540310012235.

DOI:10.1080/00365540310012235

PMID:14514149

Abstract

The aim of this study was to assess whether measurements of serum amyloid A protein (SAA) could provide additional information on the severity of acute infection beyond that obtained from C-reactive protein (CRP) assays. The SAA and CRP concentrations were analysed from the sera of 334 children hospitalized for suspected pneumonia, meningitis or sepsis. SAA significantly correlated with CRP (r = 0.682, p < 0.001) and did not alone provide any further clinically useful information. By contrast, the median ratio (and interquartile range) of SAA to CRP varied significantly between clinical conditions of different severity and was significantly lower in the patients who died [1.9 (0.0-8.9)] than in those who survived [6.8 (3.2-13.6)] (p = 0.001).

摘要

本研究的目的是评估血清淀粉样蛋白A（SAA）的检测是否能提供超出C反应蛋白（CRP）检测结果的有关急性感染严重程度的额外信息。对334名因疑似肺炎、脑膜炎或败血症住院的儿童血清中的SAA和CRP浓度进行了分析。SAA与CRP显著相关（r = 0.682，p < 0.001），且单独不能提供任何进一步的临床有用信息。相比之下，不同严重程度临床状况之间SAA与CRP的中位数比值（及四分位间距）差异显著，死亡患者的该比值[1.9（0.0 - 8.9）]显著低于存活患者[6.8（3.2 - 13.6）]（p = 0.001）。