脓毒性休克患者中C反应蛋白与血清淀粉样蛋白A的比较。
Comparison of C-reactive protein and serum amyloid a protein in septic shock patients.
作者信息
Cicarelli Domingos Dias, Vieira Joaquim Edson, Benseñor Fábio Ely Martins
机构信息
Divisão de Anestesia, Departamento de Cirurgia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, 01246-903 São Paulo, SP, Brazil.
出版信息
Mediators Inflamm. 2008;2008:631414. doi: 10.1155/2008/631414.
Septic shock is a severe inflammatory state caused by an infectious agent. Our purpose was to investigate serum amyloid A (SAA) protein and C-reactive protein (CRP) as inflammatory markers of septic shock patients. Here we evaluate 29 patients in postoperative period, with septic shock, in a prospective study developed in a surgical intensive care unit. All eligible patients were monitored over a 7-day period by sequential organ failure assessment (SOFA) score, daily CRP, SAA, and lactate measurements. CRP and SAA strongly correlated up to the fifth day of observation but were not good predictors of mortality in septic shock.
脓毒性休克是一种由感染因子引起的严重炎症状态。我们的目的是研究血清淀粉样蛋白A（SAA）和C反应蛋白（CRP）作为脓毒性休克患者的炎症标志物。在此，我们在一家外科重症监护病房开展的一项前瞻性研究中，评估了29例术后发生脓毒性休克的患者。通过序贯器官衰竭评估（SOFA）评分、每日CRP、SAA和乳酸测量，对所有符合条件的患者进行了为期7天的监测。在观察的第5天之前，CRP和SAA高度相关，但它们并非脓毒性休克患者死亡率的良好预测指标。
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