沙雷肽类的特定生物学活性。

Selected biological activities of saraines.

Caprioli V, Cimino G, De Giulio A, Madaio A, Scognamiglio G, Trivellone E

Istituto per la Chimica di Molecole di Interesse Biologico del C.N.R., Naples, Italy.

Comp Biochem Physiol B. 1992 Sep;103(1):293-6. doi: 10.1016/0305-0491(92)90447-y.

Abstract

The Mediterranean sponge Reniera sarai, Pulitzeri-Finali, 1969 (Demospongiae: Haploscleridae: Renieridae) possesses in large amounts a series of unprecedented polycyclic alkaloids, saraines 1-3 and saraines A-C. 2. The structural peculiarities of saraines, their chemical-physical characteristics, along with their relevant abundance in the sponge, prompted a study aimed at investigating their biological properties. 3. Saraines were assayed for their cytotoxic, antibacterial, insecticidal and potential antitumoral activities. These results, along with the growth inhibition of fertilized sea urchin eggs, are reported.

摘要

地中海海绵Reniera sarai，普利策里-菲纳利，1969年（寻常海绵纲：单轴海绵目：Renieridae科）大量含有一系列前所未有的多环生物碱，即海海绵素1 - 3和海海绵素A - C。2. 海海绵素的结构特点、化学物理特性以及它们在海绵中的相对丰度，促使开展一项旨在研究其生物学特性的研究。3. 对海海绵素进行了细胞毒性、抗菌、杀虫和潜在抗肿瘤活性的测定。报告了这些结果以及对受精海胆卵生长的抑制情况。