Department of Ecosustainable Marine Biotechnology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, Italy.
Department of Biology, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cin-thia 21, 80126 Naples, Italy.
Mar Drugs. 2022 Mar 31;20(4):244. doi: 10.3390/md20040244.
In the last decades, it has been demonstrated that marine organisms are a substantial source of bioactive compounds with possible biotechnological applications. Marine sponges, in particular those belonging to the class of Demospongiae, have been considered among the most interesting invertebrates for their biotechnological potential. In this review, particular attention is devoted to natural compounds/extracts isolated from Demospongiae and their associated microorganisms with important biological activities for pharmacological applications such as antiviral, anticancer, antifouling, antimicrobial, antiplasmodial, antifungal and antioxidant. The data here presented show that this class of sponges is an exciting source of compounds, which are worth developing into new drugs, such as avarol, a hydroquinone isolated from the marine sponge , which is used as an antitumor, antimicrobial and antiviral drug.
在过去的几十年中，已经证明海洋生物是具有潜在生物技术应用的生物活性化合物的重要来源。海洋海绵，特别是属于多孔动物门的那些海绵，由于其生物技术潜力，被认为是最有趣的无脊椎动物之一。在这篇综述中，特别关注了从多孔动物门及其相关微生物中分离出来的具有抗病毒、抗癌、防污、抗菌、抗疟原虫、抗真菌和抗氧化等重要生物活性的天然化合物/提取物。这里呈现的数据表明，这类海绵是一类令人兴奋的化合物来源，值得开发成新药，例如avarol，一种从海洋海绵中分离出来的对苯二酚，被用作抗肿瘤、抗菌和抗病毒药物。
