Oommen A, McNally T, Grigg J
Leicester Children's Asthma Centre, Institute for Lung Health, University of Leicester, PO Box 65, Leicester LE2 7LX, UK.
Thorax. 2003 Oct;58(10):876-9. doi: 10.1136/thorax.58.10.876.
A study was undertaken to ascertain whether systemic eosinophil activation is associated with preschool viral wheeze (PVW).
Urinary eosinophil protein X (uEPX) and serum total IgE (IgE) levels were measured in children admitted to hospital with PVW, and uEPX was measured 6 weeks after discharge. Two years after admission, current wheeze in children aged > or =5 years was determined by questionnaire. Controls were recruited from children undergoing elective surgery (normal controls) and from those with skin prick test reactivity to foods (atopic controls).
There was no difference in uEPX levels between normal controls (n=15) and atopic controls (n=8). uEPX levels were increased in children with acute PVW (n=84; p<0.001 v normal controls, p<0.01 v atopic controls) and fell on convalescence (n=20, 95% CI -217 to -31 microg/mmol creatinine, p<0.05). In children with acute PVW there was no association between uEPX and serum IgE levels or markers of clinical severity. Respiratory questionnaires were returned for 25/55 eligible children. There was no difference in uEPX level during acute PVW when stratified by "current wheeze" (n=18) or "no wheeze" (n=7) 2 years later.
Systemic eosinophil activation is associated with PVW but is not associated with serum IgE, clinical severity, or persistence of wheeze into the early school age period.
开展了一项研究以确定全身嗜酸性粒细胞活化是否与学龄前病毒性喘息（PVW）相关。
对因PVW入院的儿童测定尿嗜酸性粒细胞蛋白X（uEPX）和血清总IgE（IgE）水平，并在出院6周后测定uEPX。入院两年后，通过问卷调查确定年龄≥5岁儿童的当前喘息情况。对照组从接受择期手术的儿童（正常对照组）和对食物皮肤点刺试验呈反应性的儿童（特应性对照组）中招募。
正常对照组（n = 15）和特应性对照组（n = 8）的uEPX水平无差异。急性PVW患儿（n = 84）的uEPX水平升高（与正常对照组相比，p < 0.001；与特应性对照组相比，p < 0.01），恢复期下降（n = 20，95%可信区间 -217至-31μg/mmol肌酐，p < 0.05）。急性PVW患儿中，uEPX与血清IgE水平或临床严重程度标志物之间无关联。55名符合条件的儿童中有25名返回了呼吸问卷。按两年后“当前喘息”（n = 18）或“无喘息”（n = 7）分层时，急性PVW期间的uEPX水平无差异。
全身嗜酸性粒细胞活化与PVW相关，但与血清IgE、临床严重程度或喘息持续至学龄早期无关。
