Amini Rose-Marie, Enblad Gunilla
Department of Genetics and Pathology, Uppsala University, Uppsala University Hospital, Uppsala, Sweden.
Med Oncol. 2003;20(3):211-20. doi: 10.1385/MO:20:3:211.
Malignant lymphomas have traditionally been classified as either Hodgkin's (HL) or non-Hodgkin's lymphomas (NHL). The tumor cells in NHL have been identified as being derived from T- or B-lymphocytes, but not until recently was it possible to identify the origin of the tumor cells in HL. Differential diagnostic problems may exist with morphological overlaps between HL and NHL but do not reflect an underlying biological relationship. Recent observations indicate that HL and NHL may be more closely related than previously believed. HL and NHL may occur sequentially or simultaneously in one and the same individual and in a few cases a clonal relationship between the lymphomas has been proven. It is thus possible that a biological relationship between the disorders may exist in addition to morphological overlaps, and the purpose with this review is to summarize the different relations between HL and NHL.
恶性淋巴瘤传统上分为霍奇金淋巴瘤（HL）和非霍奇金淋巴瘤（NHL）。NHL中的肿瘤细胞已被确定来源于T淋巴细胞或B淋巴细胞，但直到最近才有可能确定HL中肿瘤细胞的起源。HL和NHL之间可能存在形态学重叠导致的鉴别诊断问题，但这并不反映潜在的生物学关系。最近的观察表明，HL和NHL的关系可能比以前认为的更为密切。HL和NHL可能在同一个体中先后或同时出现，在少数情况下，已证实淋巴瘤之间存在克隆关系。因此，除形态学重叠外，这些疾病之间可能还存在生物学关系，本综述的目的是总结HL和NHL之间的不同关系。
