The activity of Golgi-membrane galactosyltransferase in the liver of streptozotocin-diabetic rats.

The Golgi-rich membrane fraction isolated from streptozotocin-diabetic rat liver had a lower protein content than the corresponding fraction from normal liver. Its UDPgalactose-N-acetylglucosamine galactosyltransferase activity calculated per 1 g of liver or whole liver was decreased. The electron-microscopic examination of the negatively stained fraction revealed morphological changes. The morphology of the Golgi complex in thin sections of diabetic liver was also changed.