Graves Leland, Klein Robert M, Walling Anne D
Division of Metabolism, Endocrinology and Genetics, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
South Med J. 2003 Aug;96(8):824-7. doi: 10.1097/01.SMJ.0000056647.58668.CD.
Hypothyroidism is a common condition. Rarely, it may occur in combination with autoimmune failure of other endocrine glands (autoimmune polyendocrinopathy syndrome type 2, previously known as Schmidt's syndrome). In such cases, restoring normal thyroid function may precipitate adrenal failure. Clinicians should have a high index of suspicion for this condition in patients with Addison's disease, those with a family history of autoimmune endocrine gland failure, patients with one autoimmune endocrine disease who develop nonspecific or serious illness, and patients with type 1 diabetes mellitus whose insulin requirements drop without obvious explanation.
甲状腺功能减退是一种常见病症。极少数情况下，它可能与其他内分泌腺的自身免疫性衰竭同时出现（2型自身免疫性多内分泌腺病综合征，以前称为施密特综合征）。在这种情况下，恢复正常的甲状腺功能可能会引发肾上腺功能衰竭。对于患有艾迪生病的患者、有自身免疫性内分泌腺衰竭家族史的患者、患有一种自身免疫性内分泌疾病且出现非特异性或严重疾病的患者，以及1型糖尿病患者胰岛素需求量无故下降的患者，临床医生对此病症应保持高度怀疑。
