Bayless David R, Caldarera Trevor M, Harirah Hassan M
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Case Rep Perinat Med. 2022 Feb 23;11(1):20200058. doi: 10.1515/crpm-2020-0058. eCollection 2022 Jan.
Autoimmune polyglandular syndromes are uncommon heterogeneous conditions characterized by the association of two or more organ-specific endocrinopathies. Very few cases of these syndromes have been described during pregnancy. Here we report a case of autoimmune polyglandular syndrome type-2 presenting during pregnancy and complicated by preeclampsia with severe features.
The patient is a 35-year-old G7P0242 woman with a history of adrenal insufficiency, type 1 diabetes mellitus, and chronic lymphocytic thyroiditis. She was admitted to our institution at 34 weeks' gestation for preterm contractions, nausea, and lower extremity edema for a few weeks prior to admission. At 35 weeks' gestation, she developed preeclampsia with severe features requiring repeat cesarean section with good maternal and fetal outcomes. Recognizing the occurrence of this rare syndrome during pregnancy, adequate replacement of the deficient hormones, and close maternal and fetal surveillance are essential to achieving favorable outcomes.
To our knowledge, this is the first reported case of a pregnant woman with autoimmune polyglandular syndrome type-2 complicated by preeclampsia with severe features.
自身免疫性多内分泌腺综合征是罕见的异质性疾病，其特征为两种或更多种器官特异性内分泌病同时存在。孕期发生这些综合征的病例极少被描述。在此，我们报告一例妊娠期间出现的2型自身免疫性多内分泌腺综合征，并伴有重度子痫前期。
患者为一名35岁女性，孕7产0，有肾上腺功能不全、1型糖尿病和慢性淋巴细胞性甲状腺炎病史。因入院前几周出现先兆早产、恶心和下肢水肿，于孕34周入住我院。孕35周时，她发展为重度子痫前期，需要再次剖宫产，母婴结局良好。认识到孕期发生这种罕见综合征，充分补充缺乏的激素，以及密切监测母婴情况对于取得良好结局至关重要。
据我们所知，这是首例报告的患有2型自身免疫性多内分泌腺综合征并伴有重度子痫前期的孕妇病例。
