Wallenstein G
Allerg Immunol (Leipz). 1977;23(2):120-6.
Besides the strong irritative effect on the respiratory tract the isocyanates probably also have an allergenic effect. The paper gives a review of literature about immunologic in vitro- and in vivo-methods in this question. Difficulties arise especially with preparation of antigen. Isocyanates are thought to link with proteins to give antigenic conjugates. Specifity firstly depends on the isocyanate hapten.
除了对呼吸道有强烈刺激作用外，异氰酸酯可能还具有致敏作用。本文综述了关于该问题的免疫体外和体内方法的文献。特别是在抗原制备方面存在困难。异氰酸酯被认为与蛋白质结合形成抗原性结合物。特异性首先取决于异氰酸酯半抗原。
