Adams S A, Subramanian V
Department of Biology and Biochemistry, University of Bath, Bath, UK.
Angiogenesis. 1999;3(3):189-99. doi: 10.1023/a:1009015512200.
Angiogenin is a member of the ribonuclease superfamily, which shows an ever expanding collection of molecules being identified and cloned. It was initially isolated from the conditioned medium of cultured tumour cells. Its angiogenic activity appears to be critical for the maintenance and support of tumour growth. Angiogenin also plays a role in a number of non-malignant vasculoproliferative pathological conditions. Along with other related molecules, it has been identified in a wide variety of somatic tissues in adult and embryonic stages of vertebrate development. This suggests that angiogenin and related molecules are likely to play a vital role in normal physiology. Angiogenin is detectable in serum and to date has been implicated as a mitogen for vascular endothelial cells, an immune modulator with suppressive effects on polymorphonuclear leukocytes, an activator of certain protease cascades such as matrix metalloproteases and plasminogen-activated plasmin pathways, as well as an adhesion molecule. However, the role of the angiogenin family in both normal and abnormal physiology and in development will only fully be realised by genetic approaches involving gene deletion.
血管生成素是核糖核酸酶超家族的成员，该超家族所包含的已被鉴定和克隆的分子数量不断增加。它最初是从培养的肿瘤细胞条件培养基中分离出来的。其血管生成活性似乎对肿瘤生长的维持和支持至关重要。血管生成素在许多非恶性血管增生性病理状况中也发挥作用。与其他相关分子一样，在脊椎动物发育的成年和胚胎阶段的多种体细胞组织中都已鉴定出血管生成素。这表明血管生成素及相关分子可能在正常生理过程中发挥重要作用。血清中可检测到血管生成素，迄今为止，它被认为是血管内皮细胞的促有丝分裂原、对多形核白细胞具有抑制作用的免疫调节剂、某些蛋白酶级联反应（如基质金属蛋白酶和纤溶酶原激活的纤溶途径）的激活剂以及一种黏附分子。然而，只有通过涉及基因缺失的遗传学方法，才能全面了解血管生成素家族在正常和异常生理以及发育过程中的作用。
