Sultana Mst Farzana, Abo Hirohito, Kawashima Hiroto
Laboratory of Microbiology and Immunology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan.
Department of Pharmacy, Jashore University of Science and Technology, Jashore, Bangladesh.
Front Microbiol. 2022 Nov 17;13:1022945. doi: 10.3389/fmicb.2022.1022945. eCollection 2022.
Angiogenin, a well-known angiogenic factor, is crucial to the angiogenesis in gastrointestinal tumors. Human angiogenin has only one gene, whereas the murine angiogenin family has extended to incorporate six genes. Evolutionary studies have suggested functional variations among murine angiogenin paralogs, even though the three-dimensional structures of angiogenin proteins are remarkably similar. In addition to angiogenesis, the ubiquitous pattern of angiogenin expression suggests a variety of functions, such as tumorigenesis, neuroprotective, antimicrobial activity, and innate immunity. Here, we comprehensively reviewed studies on the structures and functions of human and mouse angiogenins. Understanding the structure and function of angiogenins from a broader perspective could facilitate future research related to development of novel therapeutics on its biological processes, especially in gastrointestinal cancers.
血管生成素是一种著名的血管生成因子，对胃肠道肿瘤的血管生成至关重要。人类血管生成素只有一个基因，而小鼠血管生成素家族已扩展到包含六个基因。进化研究表明，尽管血管生成素蛋白的三维结构非常相似，但小鼠血管生成素旁系同源物之间存在功能差异。除了血管生成外，血管生成素表达的普遍模式表明它具有多种功能，如肿瘤发生、神经保护、抗菌活性和先天免疫。在这里，我们全面综述了关于人和小鼠血管生成素结构与功能的研究。从更广泛的角度了解血管生成素的结构和功能，有助于未来开展与其生物学过程相关的新型治疗方法的研究，尤其是在胃肠道癌症方面。
