[输注内毒素耐受大鼠的血浆可提高大鼠失血性休克模型的存活率]
[Transfusion of plasma of endotoxin tolerant rats improves survival of hemorrhagic shock in the rat model].
作者信息
Reuter M, Bahrami S, Ackermann M, Obertacke U, Schade F U, Schlag G
机构信息
Forschergruppe Schock und MOV, Zentrum für Chirurgie, Klinikum Essen.
出版信息
Langenbecks Arch Chir Suppl Kongressbd. 1998;115(Suppl I):177-80.
To evaluate the protective effect of endotoxin tolerant plasma after hemorrhagic shock, plasma of endotoxin tolerant animals was used for resuscitation of normal rats. The transfusion of plasma of endotoxin tolerant rats improved the survival rate from 20 to 60 per cent. In the sera of endotoxin tolerant animals a TNF inhibitory activity was detected, which could be transferred by the plasma. This effect may be responsible for the protection to hemorrhagic shock.
为评估失血性休克后内毒素耐受血浆的保护作用，将内毒素耐受动物的血浆用于正常大鼠的复苏。输注内毒素耐受大鼠的血浆使存活率从20%提高到了60%。在内毒素耐受动物的血清中检测到一种TNF抑制活性，该活性可通过血浆传递。这种作用可能是对失血性休克起保护作用的原因。
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