Yao Y M
Trauma Center, Post graduate Medical College, Hospital of People's Liberation Armg Beijing.
Zhonghua Wai Ke Za Zhi. 1992 Apr;30(4):244-7, 256.
We determined the possible beneficial effect of administering antiserum against Re-LPS(F515) on experimental multiple system organ failure (MSOF) in rabbits. The results showed that there were a more significant decrease of the plasma LPS level and a shorter period to recovery than in the control group after receiving antiserum to Re-LPS. Pretreatment with antiserum can remarkably improve the function of liver, lung, kidney, blood and gastrointestinal tract. The incidence of MSOF in rabbits receiving immune sera was only 11.2% and the survival rate was increased by 40.0%. The results suggest that early passive immunotherapy may neutralize gut-derived endotoxin, inhibit endotoxin-induced mediator release and prevent development of severe complication due to sepsis. Prophylactic application of antiserum to LPS core region may provide protective effect on experimental MSOF.
我们测定了给予抗Re-LPS（F515）抗血清对兔实验性多系统器官衰竭（MSOF）的可能有益作用。结果显示，给予抗Re-LPS抗血清后，血浆LPS水平下降更为显著，恢复时间比对照组更短。抗血清预处理可显著改善肝脏、肺、肾脏、血液和胃肠道的功能。接受免疫血清的兔MSOF发生率仅为11.2%，存活率提高了40.0%。结果表明，早期被动免疫疗法可能中和肠道源性内毒素，抑制内毒素诱导的介质释放，并预防败血症所致严重并发症的发生。预防性应用LPS核心区域抗血清可能对实验性MSOF具有保护作用。
