[Protective effect of antiserum to Re-LPS on experimental multiple organ failure].

We determined the possible beneficial effect of administering antiserum against Re-LPS(F515) on experimental multiple system organ failure (MSOF) in rabbits. The results showed that there were a more significant decrease of the plasma LPS level and a shorter period to recovery than in the control group after receiving antiserum to Re-LPS. Pretreatment with antiserum can remarkably improve the function of liver, lung, kidney, blood and gastrointestinal tract. The incidence of MSOF in rabbits receiving immune sera was only 11.2% and the survival rate was increased by 40.0%. The results suggest that early passive immunotherapy may neutralize gut-derived endotoxin, inhibit endotoxin-induced mediator release and prevent development of severe complication due to sepsis. Prophylactic application of antiserum to LPS core region may provide protective effect on experimental MSOF.