[Differential modulation of CINC, NOSII and ICAM- gene expression in parenchyma and non-parenchyma cells of the liver by G-CSF--possible protective mechanisms of endotoxin-associated hepatotoxicity].

In endotoxin-exposed rat livers, G-CSF caused a reduction of CINC gene transcripts in the nonparenchymal cell fraction, which might be the mechanism for attenuation of microvascular leukocyte adherence and leukocyte-dependent tissue injury, as observed upon G-CSF application in a model of endotoxin-induced hepatotoxicity.