Mark W, Hechenleitner P, Candinas D, Hengster P, Klima G, Feichtinger J, Margreiter R
Universitätsklinik für Chirurgie, Klin. Abt. für Transplantationschirurgie, Innsbruck, Osterreich.
Langenbecks Arch Chir Suppl Kongressbd. 1998;115(Suppl I):585-8.
Guinea pig to rat orthotopic liver transplantation is associated with serious technical problems contributing to impaired graft reperfusion and a high incidence of primary non function. In order to reduce the operation time and thereby organ damage during procurement a simplified technique for reconstruction of the infrahepatic vena cava was developed and is described in detail. Reduced operation time was associated with markedly improved lobular graft perfusion and significantly better graft survival. We suggest a modification of the donor operation for the guinea pig to rat xenograft liver model for the sake of reducing non immunological factors in this difficult setting.
豚鼠到大鼠的原位肝移植存在严重的技术问题，导致移植肝再灌注受损和原发性无功能发生率高。为了减少获取过程中的手术时间，从而减少器官损伤，我们开发了一种简化的肝下腔静脉重建技术，并进行了详细描述。手术时间的缩短与小叶移植肝灌注的显著改善以及移植肝存活率的显著提高相关。为了在这种困难情况下减少非免疫因素，我们建议对豚鼠到大鼠异种移植肝模型的供体手术进行改良。
