Schwarzbach M, Willeke F, Dimitrakopoulou-Strauss A, Strauss L G, Mechtersheimer G, Hinz U, Lehnert T, Herfarth C
Chirurgische Universitätsklinik, Kirschnerstrasse 1, D-69120 Heidelberg.
Langenbecks Arch Chir Suppl Kongressbd. 1998;115(Suppl I):635-9.
Positron emission tomography (PET) with fluorine-18-fluorodeoxyglucose (FDG), carbon-11-labeled aminoisobutyric acid (AIB) and oxygen-15-labeled water (15O-labeled water) was evaluated for imaging soft tissue sarcomas (STS). Eleven pathologically confirmed STS were evaluated by PET using FDG, AIB and 15O-labeled water. All radiotracers showed an increased activity in viable tumor with a significant differentiation from normal tissue (muscle). An increased glucose metabolism in STS allowed a differentiation from normal tissue (muscle) with FDG. Furthermore, STS showed an increased AIB activity suggesting an increased "A-type" aminoacid transport. AIB therefore can be used for evaluation of STS. 15O-labeled water demonstrated an increased uptake with an overlap with blood vessel activity. These radiotracers supply information about biological properties of STS. Five patients with suspicious lesions in conventional radiodiagnostic but negative PET scans were free of local recurrence, diagnosed either by surgery or by follow-up. Two patients with PET findings suggesting local failure, ultimately demonstrated local recurrence. The differentiation of local recurrence from benign postoperative tissue alterations is encouraging and requires further evaluation.
采用氟 - 18 - 氟脱氧葡萄糖（FDG）、碳 - 11标记的氨基异丁酸（AIB）和氧 - 15标记的水（15O标记水）的正电子发射断层扫描（PET）用于软组织肉瘤（STS）成像的评估。11例经病理证实的STS患者接受了使用FDG、AIB和15O标记水的PET评估。所有放射性示踪剂在存活肿瘤中均显示活性增加，与正常组织（肌肉）有显著差异。STS中葡萄糖代谢增加使得FDG能够区分正常组织（肌肉）。此外，STS显示AIB活性增加，提示“A型”氨基酸转运增加。因此，AIB可用于评估STS。15O标记水显示摄取增加，与血管活性有重叠。这些放射性示踪剂提供了有关STS生物学特性的信息。5例在传统放射诊断中有可疑病变但PET扫描阴性的患者无局部复发，通过手术或随访确诊。2例PET结果提示局部失败的患者最终出现局部复发。将局部复发与良性术后组织改变区分开来令人鼓舞，需要进一步评估。
