大肠杆菌蛋白ybgI的晶体结构，一种具有双核金属位点的环形结构。
Crystal structure of Escherichia coli protein ybgI, a toroidal structure with a dinuclear metal site.
作者信息
Ladner Jane E, Obmolova Galina, Teplyakov Alexey, Howard Andrew J, Khil Pavel P, Camerini-Otero R Daniel, Gilliland Gary L
机构信息
Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute and the National Institute of Standards and Technology, 9600 Gudelsky Drive, Rockville, MD 20850, USA.
出版信息
BMC Struct Biol. 2003 Sep 30;3:7. doi: 10.1186/1472-6807-3-7.
BACKGROUND
The protein encoded by the gene ybgI was chosen as a target for a structural genomics project emphasizing the relation of protein structure to function.
RESULTS
The structure of the ybgI protein is a toroid composed of six polypeptide chains forming a trimer of dimers. Each polypeptide chain binds two metal ions on the inside of the toroid.
CONCLUSION
The toroidal structure is comparable to that of some proteins that are involved in DNA metabolism. The di-nuclear metal site could imply that the specific function of this protein is as a hydrolase-oxidase enzyme.
背景
基因ybgI编码的蛋白质被选为一个结构基因组学项目的目标，该项目强调蛋白质结构与功能的关系。
结果
ybgI蛋白的结构是一个由六条多肽链组成的环面，形成二聚体的三聚体。每条多肽链在环面内部结合两个金属离子。
结论
这种环面结构与一些参与DNA代谢的蛋白质的结构相似。双核金属位点可能意味着该蛋白质的特定功能是作为一种水解酶-氧化酶。
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