通过顺序进行的Sonogashira反应以及由四丁基氟化铵（TBAF）促进的环化反应，从2-碘苯胺和末端炔烃便捷地合成吲哚。
Convenient indole synthesis from 2-iodoanilines and terminal alkynes by the sequential Sonogashira reaction and the cyclization reaction promoted by tetrabutylammonium fluoride (TBAF).
作者信息
Suzuki Naoyuki, Yasaki Sakura, Yasuhara Akito, Sakamoto Takao
机构信息
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2003 Oct;51(10):1170-3. doi: 10.1248/cpb.51.1170.
PMID:14519923
Abstract
The sequential Sonogashira reaction and the cyclization reaction of various 2-iodoanilines and terminal alkynes in the presence of a palladium catalyst and tetrabutylammonium fluoride (TBAF) gave the corresponding 2-substituted indoles in good yields.
摘要
在钯催化剂和四丁基氟化铵（TBAF）存在下，各种2-碘苯胺与末端炔烃依次发生Sonogashira反应和环化反应，以良好的产率得到相应的2-取代吲哚。
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