Cunze T, Rath W, Martin M, Warnecke G, Hoffmann E, Spätling L, Kuhn W
Frauenklinik, Universität Göttingen.
Geburtshilfe Frauenheilkd. 1992 Nov;52(11):688-92. doi: 10.1055/s-2007-1026146.
Magnesium and calcium, as well as sodium and potassium, have an important influence on the physiology of contraction of the uterus. The ionic concentrations in the pre- and postmenopausal myometrium were examined. We assumed, that there are differences in the electrolytic contents because of the different functions of the corpus, isthmic part and cervix uteri during pregnancy and throughout labour. Small tissue samples from 37 premenopausal and 20 postmenopausal patients, who underwent an operation with different indications, were dissected after hysterectomy. Magnesium and calcium levels were determined by atomic absorption spectrophotometry and potassium and sodium by emission spectrometry in the wet tissue. In both groups, we found significant differences of the electrolytic contents of the myometrium. In the premenopausal uteri, the magnesium levels decrease significantly (p < 0.001) from the corpus (mean = 4.14 mmol/kg) to the cervix (mean = 2.14 mmol/kg). The same scenario can be observed for the potassium levels (Corpus mean = 56.2 mmol/kg and cervix mean = 25.4 mmol/kg). In contrary, the calcium levels (Corpus mean = 1.60 mmol/kg and cervix mean = 2.26 mmol/kg) and sodium levels (Corpus mean = 69.3 mmol/kg and cervix mean = 93.0 mmol/kg) increase significantly (p < 0.001). In the postmenopausal group, we found slightly elevated concentrations of magnesium, sodium and potassium. Only the calcium content of the corpus uteri rises up to three times about 20 years after the menopause (from mean = 1.60 mmol/kg) (p < 0.001). The electrolytic contents in the myometrium were shown to be different in the corpus, isthmus and cervix uteri.(ABSTRACT TRUNCATED AT 250 WORDS)
镁与钙以及钠与钾对子宫收缩的生理过程有着重要影响。研究人员检测了绝经前和绝经后子宫肌层中的离子浓度。我们推测，由于孕期及分娩过程中子宫体、峡部和宫颈功能不同，其电解质含量存在差异。对37名绝经前和20名绝经后因不同指征接受手术的患者，在子宫切除术后解剖取出小组织样本。通过原子吸收分光光度法测定湿组织中的镁和钙水平，通过发射光谱法测定钾和钠水平。在两组中，我们均发现子宫肌层电解质含量存在显著差异。在绝经前子宫中，镁水平从子宫体（平均值 = 4.14 mmol/kg）到宫颈（平均值 = 2.14 mmol/kg）显著降低（p < 0.001）。钾水平也呈现相同情况（子宫体平均值 = 56.2 mmol/kg，宫颈平均值 = 25.4 mmol/kg）。相反，钙水平（子宫体平均值 = 1.60 mmol/kg，宫颈平均值 = 2.26 mmol/kg）和钠水平（子宫体平均值 = 69.3 mmol/kg，宫颈平均值 = 93.0 mmol/kg）显著升高（p < 0.001）。在绝经后组中，我们发现镁、钠和钾的浓度略有升高。仅子宫体的钙含量在绝经后约20年升高至三倍左右（从平均值 = 1.60 mmol/kg）（p < 0.001）。子宫肌层中的电解质含量在子宫体、峡部和宫颈中显示出差异。（摘要截选至250字）
