Lobbedez Thierry, Comoz François, Renaudineau Eric, Pujo Myriam, Ryckelynck Jean-Philippe, Hurault de Ligny Bruno
Nephrology and Pathology Department, Caen University Hospital, Caen, France.
Am J Kidney Dis. 2003 Oct;42(4):E2-6. doi: 10.1016/s0272-6386(03)00917-x.
Recurrence of crescentic necrotizing glomerulonephritis after renal transplantation is rare. Successful renal transplantation in patients with antineutrophil cytoplasmic autoantibody (ANCA) glomerulonephritis has been reported. The presence of ANCA at transplantation does not appear to increase the rate of relapse after kidney allografting. Therapy with cyclophosphamide and corticoids usually is effective. We report a case of recurrent perinuclear ANCA crescentic necrotizing glomerulonephritis immediately after renal transplantation that was treated successfully by cyclophosphamide, plasma exchange, and intravenous polyvalent immunoglobulin.
新月体性坏死性肾小球肾炎在肾移植后复发罕见。有报道称抗中性粒细胞胞浆自身抗体（ANCA）相关性肾小球肾炎患者肾移植成功。移植时ANCA的存在似乎并未增加肾移植后复发率。环磷酰胺和皮质类固醇治疗通常有效。我们报告1例肾移植后即刻复发的核周型ANCA新月体性坏死性肾小球肾炎患者，经环磷酰胺、血浆置换及静脉注射多价免疫球蛋白治疗成功。
