Maurage Claude-Alain, Ruchoux Marie-Magdeleine, de Vos Rob, Surguchov Andrei, Destee Alain
Department of Neuropathology, R. Salengro Hospital, CHRU, Lille Cedex, France.
Ann Neurol. 2003 Oct;54(4):542-7. doi: 10.1002/ana.10730.
Visual hallucinations are a core feature of dementia with Lewy bodies. Their pathophysiology is not well understood, because neither clinical nor histological data have shown their basic mechanisms. Here, we report the presence of pale inclusions in the outer plexiform layer of the retina in a patient with dementia with Lewy bodies. These inclusions are related to cytoskeletal disorganization of the cones at ultrastructural level and modifications of the immunohistochemical pattern of distribution of synucleins in the retina. These modifications may participate in the visual impairment in dementia with Lewy bodies.
视幻觉是路易体痴呆的核心特征。其病理生理学尚未完全明确，因为临床和组织学数据均未揭示其基本机制。在此，我们报告了1例路易体痴呆患者视网膜外丛状层存在苍白包涵体。这些包涵体在超微结构水平上与视锥细胞的细胞骨架紊乱有关，并且视网膜中突触核蛋白免疫组化分布模式也发生了改变。这些改变可能参与了路易体痴呆的视力损害。
