de Sutter P, van der Elst J, Dhont M
Universitair Ziekenhuis, Infertiliteitcentrum, De Pintelaan 185, B-9000 Gent, Belgie.
Ned Tijdschr Geneeskd. 2003 Sep 6;147(36):1741-6.
To describe the results of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) of Dutch patients who came to Ghent University Hospital (GHU), Belgium, for treatment, during the period 1993-2002.
Retrospective data collection, description and analysis.
Dutch and Belgian patients were compared with respect to: age, indication for treatment, duration of infertility, stimulation protocol, number of ampoules of gonadotrophins, duration of stimulation, number of follicles, number of oocytes, number of fertilized oocytes, number of transferred embryos, quality of transferred embryos, number of frozen embryos, pregnancy, outcome of pregnancy, duration of pregnancy, sex and weight of the child or children.
In the period 1993-2002 (10 years), 6099 treatment cycles were carried out in Belgian and 4801 in Dutch couples in the GHU. The duration of infertility was longer for the Dutch than for the Belgian couples and the Dutch women were on average three years older than the Belgian. The male infertility rate and proportion of ICSI cycles was higher for the Dutch than for the Belgian couples. In 17% of the cycles surgically retrieved sperm was used because of azoospermia. The numbers of follicles, oocytes retrieved, as well as the number of fertilized oocytes were all larger for the Belgian than for the Dutch patients. An equal number of embryos was transferred in both groups (2.24). The ongoing pregnancy rate per cycle was a little lower for the Dutch (23.2%) than for the Belgian couples (25.3%). The percentage multiple pregnancies was not different (27.8% for the Belgian and 25.1% for the Dutch patients). The Dutch singleton babies were born six days later than the Belgian, but the children differed in no other way. From 1996 to 2000 the ongoing pregnancy rate was 23.8% per first cycle for Dutch patients treated in the UHG, as compared to 19.4% in the Netherlands.
Dutch patients treated in the GHU differed from Belgian patients in that they had a longer duration of infertility and a longer history of previously failed treatments. Although the pregnancy results were slightly lower for Dutch than for Belgian patients, this does not seem to be clinically very relevant, especially not in view of the overall Dutch national results.
描述1993年至2002年期间前往比利时根特大学医院（GHU）接受治疗的荷兰患者的体外受精（IVF）和卵胞浆内单精子注射（ICSI）结果。
回顾性数据收集、描述与分析。
对比荷兰和比利时患者的以下方面：年龄、治疗指征、不孕持续时间、刺激方案、促性腺激素安瓿数量、刺激持续时间、卵泡数量、卵母细胞数量、受精卵母细胞数量、移植胚胎数量、移植胚胎质量、冷冻胚胎数量、妊娠情况、妊娠结局、妊娠持续时间、孩子的性别和体重。
在1993年至2002年（10年）期间，GHU对比利时夫妇进行了6099个治疗周期，对荷兰夫妇进行了4801个治疗周期。荷兰夫妇的不孕持续时间比比利时夫妇长，荷兰女性平均比比利时女性大三岁。荷兰夫妇的男性不育率和ICSI周期比例高于比利时夫妇。在17%的周期中，由于无精子症而使用了手术获取的精子。比利时患者获取的卵泡、卵母细胞数量以及受精卵母细胞数量均多于荷兰患者。两组移植的胚胎数量相同（2.24个）。荷兰患者每个周期的持续妊娠率略低于比利时夫妇（23.2%对比25.3%）。多胎妊娠百分比无差异（比利时为27.8%，荷兰患者为25.1%）。荷兰单胎婴儿比比利时婴儿晚六天出生，但孩子在其他方面并无差异。1996年至2000年，在UHG接受治疗的荷兰患者第一个周期的持续妊娠率为23.8%，而在荷兰为19.4%。
在GHU接受治疗的荷兰患者与比利时患者的不同之处在于，他们的不孕持续时间更长，先前治疗失败的病史更长。尽管荷兰患者的妊娠结果略低于比利时患者，但这在临床上似乎并非非常相关，尤其是考虑到荷兰全国的总体结果。
