Kremer J A M, Bots R S G M, Cohlen B, Crooij M, van Dop P A, Jansen C A M, Land J A, Laven J S E, Kastrop P M M, Naaktgeboren N, Schats R, Simons A H M, van der Veen F
Universitair Medisch Centrum St Radboud, afd. Gynaecologie, Nijmegen.
Ned Tijdschr Geneeskd. 2008 Jan 19;152(3):146-52.
To present the numbers and results of Dutch IVF treatment from 1996-2005 and to describe trends and differences between centres.
Retrospective data-collection, description and analysis.
The annual statistics from all Dutch IVF centres covering the years 1996-2005 were collected, described and analysed.
During this period 138,217 IVF or intracytoplasmic sperm injection (ICSI) cycles were started and 14,881 transfers of frozen-thawed embryos (cryo transfers) were performed. The number of ICSI treatments, in particular, increased to more than 6000 cycles during this period. These treatments resulted in 30,488 ongoing pregnancies (22.1% per cycle started; 19.1% for IVF and 23.4% for ICSI). The ongoing pregnancy rate per cycle increased from 17.6% in 1996 to 24.4% in 2005. The increase after cryo transfers was remarkable (from 9.4% to 17.6%). It is estimated that during this period, about 1 in 52 newborns in the Netherlands was an IVF or ICSI child (1996: 1 in 77, 2005: 1 in 43). There were differences between the individual centres regarding the ongoing pregnancy rate per cycle (range: 15.0-26.4%), the percentage of ICSI (range 20-58%), the percentage of cryo transfers per cycle (range: 4-22%) and the multiple pregnancy rate (range 5-27% in 2005).
In the Netherlands the pregnancy rate has increased over the last 10 years as has the number of IVF treatments. Cryo transfers have become increasingly important and the multiple pregnancy rate has decreased. Although thanks to the collaboration of all centres, the current registry produces important data and works well, there are a number of limitations e.g. the retrospective nature with no validation, which must be tackled over the coming years.
呈现1996年至2005年荷兰体外受精（IVF）治疗的数量和结果，并描述各中心之间的趋势和差异。
回顾性数据收集、描述与分析。
收集、描述并分析了荷兰所有IVF中心1996年至2005年的年度统计数据。
在此期间，共启动了138,217个IVF或卵胞浆内单精子注射（ICSI）周期，并进行了14,881次冻融胚胎移植（冷冻移植）。在此期间，ICSI治疗的数量尤其增加到了6000多个周期。这些治疗导致了30,488例持续妊娠（每个启动周期为22.1%；IVF为19.1%，ICSI为23.4%）。每个周期的持续妊娠率从1996年的17.6%上升到2005年的24.4%。冷冻移植后的增加显著（从9.4%到17.6%）。据估计，在此期间，荷兰约每52名新生儿中就有1名是通过IVF或ICSI出生的孩子（1996年：每77名中有1名，2005年：每43名中有1名）。各中心在每个周期的持续妊娠率（范围：15.0 - 26.4%）、ICSI的百分比（范围20 - 58%）、每个周期的冷冻移植百分比（范围：4 - 22%）以及多胎妊娠率（2005年范围5 - 27%）方面存在差异。
在荷兰，过去10年中妊娠率和IVF治疗数量均有所增加。冷冻移植变得越来越重要，多胎妊娠率有所下降。尽管由于所有中心的合作，当前登记处产生了重要数据且运行良好，但仍存在一些局限性，例如回顾性性质且未经验证，这些问题在未来几年必须加以解决。
