Gorokhovskaia G N, Zav'ialova A I, Martynov A I
Ter Arkh. 2003;75(8):26-32.
To study the data of 24-h monitoring of blood pressure (MBP) and effects of an ACE inhibitor lisinopril (diroton) in hypertensive patients with polycythemia vera (PV).
20 patients with arterial hypertension of degree II and III with PV aged 41 to 77 years. Mean duration of AH and PV was 11.8 +/- 2.2 and 2.0 +/- 0.2 years, respectively. Diroton was given as monotherapy in a single morning dose 10-40 mg for 4 weeks. 24-h MBP was made before the treatment and on the 4th week of the treatment. In addition to standard estimations, hour-to-hour double product (DP) was estimated.
After 4 weeks of diroton therapy there was a 12.2%, 9.5%, 25% and 15.4% fall in mean 24-h systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), DP, respectively. A positive effect was registered on variability and 24-h profile of BP. A response was achieved in 85% patients. The target level of mean 24-h blood pressure < 135/85 mm Hg was achieved in 65%, and 10% fall in SBD and/or DBP in 20% patients. ACE inhibitors' side effect--severe dry cough--was not encountered.
PV aggravates arterial hypertension. Monotherapy with diroton effectively controls BP in hypertensive patients with PV in a 4-week course intake in a single morning dose and is well tolerated.
研究真性红细胞增多症（PV）高血压患者的24小时动态血压（MBP）数据以及血管紧张素转换酶抑制剂赖诺普利（得利通）的疗效。
20例年龄在41至77岁之间的II级和III级动脉高血压合并PV患者。平均高血压和PV病程分别为11.8±2.2年和2.0±0.2年。得利通作为单一疗法，每天早晨单次给药10 - 40毫克，持续4周。在治疗前和治疗第4周进行24小时动态血压监测。除了标准评估外，还评估逐小时的双乘积（DP）。
经过4周的得利通治疗后，24小时平均收缩压（SBP）、舒张压（DBP）、脉压（PP）、DP分别下降了12.2%、9.5%、25%和15.4%。在血压变异性和24小时血压轮廓方面有积极效果。85%的患者有反应。65%的患者达到了24小时平均血压<135/85毫米汞柱的目标水平，20%的患者SBP和/或DBP下降了10%。未出现血管紧张素转换酶抑制剂的副作用——严重干咳。
PV会加重动脉高血压。得利通单一疗法在4周疗程中每天早晨单次给药可有效控制PV高血压患者的血压，且耐受性良好。
