Farouk M, Geoghegan J G, Pruthi R S, Thomson H J, Pappas T N, Meyers W C
Department of Surgery, Duke University Medical Center, Durham, NC 27710.
Gut. 1992 Nov;33(11):1562-5. doi: 10.1136/gut.33.11.1562.
The effect of intracerebroventricular injection of neuropeptide Y on biliary secretion was studied in conscious dogs, prepared with gastric and duodenal fistulas and cerebroventricular guides. Bile secretion was increased in a dose-dependent fashion by intracerebroventricular neuropeptide Y. The peak increase was seen after 500 pM/kg of neuropeptide Y which resulted in a 30 x 2% increase in bile flow over the period 30-150 minutes after injection. (
23 x 2 (1 x 2) ml/2 hours; neuropeptide Y 500 pM/kg: 30 x 5 (1 x 1) ml/2 hours). Biliary lipid composition was not altered significantly but bicarbonate output was increased at all doses tested. Intravenous infusion of neuropeptide Y (1000 pM) for 1 hour had no significant effect. Intracerebroventricular neuropeptide Y (1000 pM/250-300 mg body weight) also increased bile flow in urethane-anaesthetised rats. This effect was abolished by cervical vagotomy. The demonstration of a central stimulation of alkaline bile flow suggests that bile secretion may be subject to central modulation.
在制备有胃瘘和十二指肠瘘以及脑室导管的清醒犬中，研究了脑室内注射神经肽Y对胆汁分泌的影响。脑室内注射神经肽Y可使胆汁分泌呈剂量依赖性增加。注射后30 - 150分钟内，500 pM/kg的神经肽Y使胆汁流量达到峰值增加，增加了30×2%。（对照：23×2（1×2）ml/2小时；神经肽Y 500 pM/kg：30×5（1×1）ml/2小时）。胆汁脂质成分无显著改变，但在所有测试剂量下碳酸氢盐输出均增加。静脉输注神经肽Y（1000 pM）1小时无显著影响。脑室内注射神经肽Y（1000 pM/250 - 300 mg体重）也可增加氨基甲酸乙酯麻醉大鼠的胆汁流量。这种作用被颈迷走神经切断术消除。碱性胆汁流量的中枢刺激作用表明胆汁分泌可能受中枢调节。
