Gel'tser B I, Kotel'nikov V N
Klin Med (Mosk). 2003;81(8):53-6.
To assess a hypotensive activity of nebivolol (nebilet) including its action on the 24-h profile and baroreceptor control of arterial pressure (AP), vegetative regulation of the heart and vasculomotor endothelial function in AP patients, 30 AH patients were given nebivolol in a dose 5 mg/day for 8 weeks. The results of the treatment show that nebivolol effectively maintains a safe 24-h control of AP, acts positively on chronostructure of AP 24-h profile, produced no clinically significant side effects, corrects vegetative heart regulation and improves baroreceptor AP control. Moreover, nebilet modulates a stable vasodilating effect which improves function of vascular endothelium, initiates regression of left ventricular myocardium hypertrophy by raising its elasticity without changing much its contractile function. Thus, nebivolol is a highly effective drug for treatment of arterial hypertension which corrects a wide spectrum of unfavourable shifts in cardiovascular system function.
为评估奈必洛尔（奈比洛尔）的降压活性，包括其对24小时血压变化曲线以及动脉血压（AP）压力感受器控制的作用、对AP患者心脏的自主调节和血管运动内皮功能的影响，30例AP患者接受剂量为5毫克/天的奈必洛尔治疗，疗程8周。治疗结果表明，奈必洛尔有效地维持了对AP的安全24小时控制，对AP 24小时血压变化曲线的时间结构有积极作用，未产生具有临床意义的副作用，纠正了心脏自主调节功能并改善了压力感受器对AP的控制。此外，奈比洛尔调节稳定的血管舒张作用，改善血管内皮功能，通过提高左心室心肌弹性而启动左心室心肌肥厚的消退，而其收缩功能变化不大。因此，奈必洛尔是治疗动脉高血压的高效药物，可纠正心血管系统功能中广泛的不利变化。
