Tkacheva O N, Vertkin A L, Barabashkina A V, Vasil'eva A V, Razguliaeva N F
Ter Arkh. 2006;78(10):56-61.
To study nebivolol efficacy in pregnant and puerperal women with hypertension.
Monitoring of endothelial function, central and peripheral hemodynamics (HD), myocardial function, intrarenal circulation and microalbuminuria (MAU) was performed in 90 pregnant (67 hypertensive and 23 normotensive) and 18 puerperal women who were diagnosed to have hypertension in pregnancy. The above parameters were estimated in 23 hypertensive gravidas and 18 puerperas treated with nebivolol.
Hypertensive gravidas had marked endothelial dysfunction (ED), impaired intrarenal HD, MAU, high total peripheral vascular resistance and left ventricular myocardial mass index (LVMMI). The puerperas with hypertension had ED, MAU, frequently HD disorders and a trend to a LVMMI rise. Nebivolol effectively reduced blood pressure, had a nephroprotective action, and improved HD and endothelial function.
Nebivolol (a highly selective beta 1-adrenoblocker) administration is effective pathogenetic treatment of pregnant and puerperal women with hypertension and may improve short- and long-term prognoses of such patients.
研究奈必洛尔对妊娠及产后高血压妇女的疗效。
对90例妊娠（67例高血压患者和23例血压正常者）及18例产后被诊断为妊娠期高血压的妇女进行内皮功能、中心和外周血流动力学（HD）、心肌功能、肾内循环及微量白蛋白尿（MAU）监测。对23例接受奈必洛尔治疗的高血压孕妇和18例产后高血压妇女进行上述参数评估。
高血压孕妇存在明显的内皮功能障碍（ED）、肾内血流动力学受损、MAU、总外周血管阻力高及左心室心肌质量指数（LVMMI）升高。产后高血压妇女有ED、MAU，常伴有血流动力学紊乱且有LVMMI升高趋势。奈必洛尔有效降低血压，具有肾脏保护作用，并改善血流动力学和内皮功能。
给予奈必洛尔（一种高度选择性的β1肾上腺素能阻滞剂）是治疗妊娠及产后高血压妇女的有效病因治疗方法，可改善此类患者的短期和长期预后。
